Innoen 5% Glucose Physiological Saline Injection

Adult administration

Typically, 500–1,000 mL per day for adults is administered in 2–3 divided doses via slow intravenous infusion. The administration rate is 250–500 mL per hour (60–120 drops per minute); for the elderly, it is 250 mL per hour (60 drops per minute).

Child administration

For infants and young children, administer 15–60 mL per hour (4–15 drops per minute).

This medication contains glucose, which can increase the consumption of Vitamin B1 (thiamine) in the body during intravenous administration. Therefore, there is a risk of sudden severe Vitamin B1 deficiency, and caution is warranted. This medication should not be administered to patients with excessive fluid or storage-related dehydration, low potassium levels in the blood, or high sodium levels. It should be administered with caution to patients with decreased kidney function, heart failure, hyperosmolar dehydration, decreased urine output due to urinary obstruction, diabetes, high chloride levels in the blood, and very low sodium levels in the blood. Rapid or large-volume administration of this medication may cause side effects such as cerebral edema, pulmonary edema, peripheral edema, acidosis, and water intoxication. In particular, when administered rapidly to neonates or premature infants, there is a higher risk of water intoxication, requiring careful attention. Additionally, there is a possibility of thrombosis at the injection site, so monitoring is necessary. During administration, blood sugar, serum electrolytes, and fluid balance status should be regularly checked to confirm there are no abnormalities. Particular caution is needed when using this medication in pregnant women, nursing mothers, women of childbearing age, neonates and children, and the elderly. The container of this medication is made from PVC material that contains a plasticizer called DEHP, which has been reported to affect reproductive development in animal studies; however, the actual risk is very low during use. It should only be used during pregnancy when the therapeutic benefits outweigh the potential risks to the fetus. Glucose injection during labor may cause complications related to hyperglycemia for both the mother and the fetus, necessitating careful judgment. Neonates, especially preterm infants or low birth weight infants, are more prone to difficulties in blood sugar regulation and the risk of hypoglycemia or hyperglycemia, requiring close monitoring. Hypoglycemia can lead to brain injury or seizures, while hyperglycemia is associated with various serious complications. In infants and the elderly, rapid or prolonged administration should be avoided, and in particular, in the elderly, careful administration is required to prevent circulatory overload in patients with heart or kidney failure. In cases of overdose, treatment may be required to eliminate excess fluid using diuretics. Before administration, the skin and injection equipment should be thoroughly disinfected to prevent infections, and in cold periods, the medication should be warmed to body temperature before use. Any unused medication after opening should be discarded immediately. The injection should be administered slowly intravenously, and to prevent air embolism caused by air in the container, continuous connection of the container should be avoided. This medication should be stored at room temperature, and it is important to handle it properly to maintain quality.

Serious side effects

Severe swelling (cerebral edema, pulmonary edema, peripheral edema), abnormal urination (decreased urine output), potential for severe allergic reactions

Mild side effects

• Cerebral edema
• pulmonary edema
• peripheral edema
• acidosis
• water intoxication
• thrombosis

This medication should be stored in a sealed container to prevent air or moisture ingress, with an important storage temperature maintained between 1°C and 30°C at room temperature. Proper storage temperatures will ensure the medication's effects are safely maintained.

Appearance

A colorless, transparent injectable solution filled in a colorless, transparent plastic container made of high-density polyethylene, packaged in a translucent exterior.

Package unit

500, 1000 milliliters