Rithain Injection 4% (Lidocaine Hydrochloride)

Adult administration

Liquid (2% viscous): The maximum single dose should not exceed 4.5 mg per kg of body weight for lidocaine hydrochloride, and the total administered dose should not exceed 300 mg (15 mL). For irritation of the oral and pharyngeal mucosa, administer 300 mg (15 mL). For oral use, it should be held in the mouth and then spat out, and for pharyngeal use, it should be held in the mouth and then swallowed. Reapplication is prohibited within 3 hours and usage of more than 8 times within 24 hours is prohibited. Gel (2%): - Male urethra

This medication should not be used in patients with severe bleeding or shock, patients with inflammation at the injection site or sepsis, and patients who are allergic to this medication or other amide-type local anesthetics. Caution is required when administering to patients with central nervous system disorders, pregnant women, elderly individuals, patients with severe hypertension, and patients with severe spinal deformities. Serious reactions such as shock, drop in blood pressure, abnormal pulse, and respiratory depression may occur while using this medication, so the patient should be closely monitored, and if any abnormal symptoms appear, administration should be immediately stopped, and appropriate treatment should be received. Furthermore, a serious side effect called malignant hyperthermia can rarely occur, so if there is a sudden increase in body temperature, muscle rigidity, or blood discoloration, administration should be stopped immediately, and professional treatment should be sought. Central nervous system symptoms may include tremors, seizures, drowsiness, anxiety, dizziness, and nausea, which should be promptly treated if they occur. This medication can cause allergic reactions like skin rashes or swelling and, in severe cases, anaphylaxis, so any unusual symptoms should be reported to the healthcare provider immediately. During the use of local anesthetics, sudden shock or symptoms of poisoning can occur, so preparations for emergency treatment are always necessary. Careful observation of the patient's general condition is required during administration, using the lowest effective concentration and minimum dose possible, particularly being cautious when used in conjunction with vasoconstrictors. Especially when injected in highly vascular areas, the absorption is rapid, so it is recommended to use only a small volume. Ensure that the injection needle does not enter blood vessels or spinal fluid, and it is advisable to administer slowly if possible. This medication should not be used in conjunction with certain vasoconstrictors, and caution is necessary when combined with some drugs, as it may lead to cardiac function suppression or increased toxicity. The safety of this medication in pregnant women has not been established, so it should only be used when the benefits of treatment outweigh the risks. Elderly individuals may be more sensitive to the effects of the drug, so dosage adjustments and monitoring of the patient's condition are important. Lastly, the metabolites of this medication cannot be excluded from the possibility of causing mutations or tumor development with prolonged high-dose use, so it is advisable not to administer at high concentrations for extended periods.

Serious side effects

• Hypotension, facial pallor, abnormal pulse, respiratory depression → shock
• Hives, swelling → severe allergic reaction
• Malignant hyperthermia (tachycardia, arrhythmia, blood pressure fluctuations, rapid increase in body temperature, muscle rigidity, blood discoloration, hyperventilation, sweating, acidosis, hyperkalemia, myoglobinuria) → severe adverse reaction
• Anaphylaxis → severe allergic reaction
• Tremors, seizures → severe neurological symptoms

Mild side effects

• Tremors
• drowsiness
• anxiety
• excitement
• neglect
• dizziness
• nausea
• vomiting
• hives
• swelling

This medication should be stored in a sealed container to avoid exposure to air, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius. By storing it this way, the efficacy of the drug can be maintained and degradation prevented.

Appearance

Colorless, transparent solution filled in a colorless, transparent vial

Package unit

10 vials/box (20 mL/vial)