Haloxine Tablet (Hydroxychloroquine Sulfate)

Adult dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases Adults - The initial dose is 200～400mg per day. If 400mg is administered, divide the dose. If an effect is observed after administration, reduce the dose to 200mg per day; if the effect is inadequate, increase it to 400mg per day. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. 2. Malaria 1) Treatment Adults - For treatment of acute disease, administer 800mg initially, followed by 400mg at 6∼8-hour intervals for 3 additional doses, for a total of 2g over 2 days. For treatment of acute disease caused by Plasmodium falciparum or Plasmodium vivax (P.falciparum, P.vivax), a single dose of 800mg may be administered. 2) Prevention Adults - Administer 6mg/kg once weekly (usually 400mg once weekly) starting 2 weeks before exposure. * It may take several weeks for this medicine to take effect, whereas adverse effects may occur sooner. * When used for photosensitive diseases, administer only when there is substantial exposure to light.

Child dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day; it must not exceed the adult dose regardless of body weight. * For rheumatoid arthritis, juvenile rheumatoid arthritis, and discoid and systemic lupus erythematosus, discontinue treatment if symptoms do not improve after 6 months of use. 2. Malaria 1) Treatment Children - Administer 10mg/kg of chloroquine initially, followed by 5mg/kg at 6-8-hour intervals for 3 additional doses, for a total of 25mg/kg over 2 days. However, the adult dose must not be exceeded. 2) Prevention Children - Administer 6mg/kg once weekly starting 2 weeks before exposure. For children weighing 30∼40kg or less, even 1 tablet (200mg) exceeds the appropriate dose; therefore, administration is not recommended.

This medication should not be administered to certain patients. For example, it is not to be used in individuals allergic to this drug or similar compounds, those who already have macular degeneration, or those taking medications that may cause visual impairment. Additionally, children requiring long-term treatment and individuals who are pregnant or breastfeeding should not take this medication. There are also patients who require careful administration. Those allergic to quinine, psoriasis patients, individuals with specific enzyme deficiencies, liver or kidney disease, severe gastrointestinal disorders, neurological disorders, blood disorders, or porphyria should exercise caution when taking this medication. This medication can cause various adverse reactions in the eye. Symptoms such as visual distortion, retinal abnormalities, corneal changes, and pigmentation changes may occur. Initially, stopping the medication will lead to recovery, but neglecting these symptoms may cause permanent damage. The skin may also experience rashes, urticaria, hair loss, and in severe cases, serious skin reactions like Stevens-Johnson syndrome. In the gastrointestinal tract, symptoms like nausea, diarrhea, loss of appetite, and abdominal pain may occur, while the central nervous system may experience headaches, drowsiness, hallucinations, and anxiety. Muscle weakness or neuromuscular issues have also been reported, along with the risk of blood system abnormalities, cardiac arrhythmias, liver dysfunction, and mental health issues. Regular ophthalmic examinations must be conducted every 3-6 months during the course of this medication, and should any symptoms of visual impairment arise, use must be discontinued immediately and medical advice sought. Patients with poor liver or kidney function need to monitor blood drug levels and adjust the dosage accordingly. This medication may interact with other drugs, so caution is advised, especially with medications that may cause cardiac arrhythmias or those that affect liver metabolism. Pregnant or breastfeeding individuals should avoid this medication due to potential effects on the fetus or infant. Overdose can lead to serious side effects; therefore, the dosage must be strictly adhered to, and if an overdose is suspected, immediate emergency measures should be taken. Finally, this medication should be kept out of the reach of children, and it is safest not to transfer it to another container.

Visual disturbances, retinal abnormalities, decreased corneal sensitivity, corneal opacity, changes in pigmentation, visual impairment, color halos, glare, skin rash, urticaria, changes in skin and mucosal pigmentation, hair depigmentation, alopecia, vesicular rash, erythema multiforme, mucocutaneous syndrome, photophobia, exfoliative dermatitis, Sweet's syndrome, severe skin adverse reactions, psoriasis flare, acute generalized pustular psoriasis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, myasthenia, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restrictive neuroexcitability, mood swings, nightmares, tinnitus, dizziness, hearing loss, unstable mood fluctuations, psychosis, seizures, skeletal myopathy, neuromuscular disorder, perceptual changes, decreased tendon reflexes, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, left ventricular hypertrophy, conduction disturbances, abnormal liver function test results, acute liver failure, hepatocellular damage, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver damage, fulminant hepatic failure, depression, hallucinations, anxiety, agitation, confusion, delusions, mania, sleep disorders, weight loss, malaise

This medication should be stored in a sealed container to protect it from air and moisture, and the storage temperature should be at room temperature, meaning not too hot or too cold, consistent with typical indoor temperatures. Storing this way helps maintain the medication's effectiveness and prevents degradation.

Appearance

White coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle