Ferbon Tablet (Polyneate Calcium)

Adult dosage

Injection 1. Methotrexate conventional therapy: Administer 6-12 mg intramuscularly every 6 hours, four times a day. 2. Methotrexate-Polynucleotide rescue therapy: Administer 15 mg intravenously every 3 hours, 9 times starting 3 hours after stopping methotrexate, followed by 8 intravenous or intramuscular injections every 6 hours. 3. Combination therapy with 5-Fluorouracil (5-FU) in metastatic colorectal cancer: 1)

This medication is not suitable for the treatment of pernicious anemia due to vitamin B12 deficiency or other macrocytic anemias. Even if neurological symptoms continue to progress, attention is required as hematological status may improve. In the case of injection form, when opening the ampoule, glass fragments may be mixed, so caution should be exercised during use, especially when administering to children or the elderly. Women who are pregnant or breastfeeding should avoid using this medication, and careful consideration should be given in certain situations. This medication may cause side effects such as hypersensitivity reactions, urticaria, temporary pain at the injection site, fever, central nervous system disorders (paralysis, excitement, depression). Also, interactions with other drugs may lead to various adverse reactions such as diarrhea, skin reactions, oral mucositis, so caution is necessary. This medication should be used under the guidance of a physician experienced in chemotherapy, and blood concentrations should be measured during treatment to determine appropriate dosage and treatment duration. If renal function is impaired or bodily fluids are abnormally accumulated, drug excretion may be delayed, necessitating dosage adjustment. This medication may interact with certain anticancer drugs, reducing their effects or increasing side effects, so it is essential to discuss the concurrent medications with a physician. Pregnant or breastfeeding women should only use this medication if absolutely necessary, and should not be administered in combination with 5-FU. Elderly patients require careful observation due to decreased bodily function and increased side effects risk. This medication is contraindicated for intrathecal administration. When administering intravenously, the infusion rate should be limited to below 160mg per minute due to calcium content. Keep this medication out of the reach of children and store it in the original container to prevent degradation in quality or misuse.

Serious side effects

Urticaria, anaphylactic reaction

Mild side effects

• Vascular pain
• transient pain
• fever
• excitement
• depression
• diarrhea
• skin reactions
• skin dryness
• oral mucositis
• conjunctivitis

This medication should be stored in a tightly closed container that blocks light and prevents air from entering. The storage temperature should be maintained at room temperature between 1 degree and 30 degrees.

Appearance

White to whitish round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle