Mebarochin 5 mg (Pravastatin Sodium)

Adult dose

Before starting treatment, patients should begin a low-cholesterol diet and continue during treatment. The usual starting dose is 10 mg, 20 mg, or 40 mg taken as a single dose once daily. Depending on the patient's response, the dose may be increased up to a maximum of 40 mg, with the maintenance dose being 10 to 40 mg once daily. For patients with a history of myocardial infarction or unstable angina, the treatment goal of reducing the risks of 'myocardial infarction, need for cardiovascular revascularization, ischemic stroke, transient ischemic attack' can be achieved with pravastatin sodium 40 mg/day. Lower doses have not been studied for effectiveness. 2) Patients receiving immunosuppressants like cyclosporine: the initial dose is 5 to 10 mg, with very cautious dose adjustments. The maximum daily dose is 20 mg. However, in kidney transplant recipients, it should not exceed 10 mg per day.

This medication should not be used in certain patients. For example, it should not be administered to individuals who are allergic or hypersensitive to this drug, those with severe liver disease, pregnant or breastfeeding women, children, or patients with severe liver or kidney dysfunction. Additionally, it should not be given to patients with muscle diseases or those with issues related to bile flow, as well as patients with specific blood cholesterol abnormalities. Since this drug is primarily metabolized in the liver, patients with poor liver function should use it with caution. Patients with severely impaired kidney function also need to be cautious, as the risk of muscle damage may be increased when used with certain medications. Care should be taken when administering to patients who consume alcohol excessively or have muscle weakness. During treatment, adverse reactions such as skin rashes, dyspepsia, liver function abnormalities, kidney function changes, muscle pain, or weakness may occur, so immediate consultation with a physician should be sought if these symptoms arise. In particular, muscle-related adverse reactions can be serious, so if muscle pain, weakness, fever, etc., occur, healthcare professionals should be notified immediately. This drug is used for the treatment of hypercholesterolemia, and regular blood lipid and liver function tests should be conducted before and during its use. Moreover, this medication can be harmful to the fetus during pregnancy, so women who are pregnant or may become pregnant should not take it, and it should be avoided during breastfeeding. The elderly may have decreased bodily function, thus dose adjustments may be necessary. This drug may interact with other medications, so patients should inform their doctors or pharmacists of any medications they are currently taking. In case of overdose, immediate medical attention should be sought for appropriate tests, including liver function tests. Finally, this medication is most effective when taken after dinner, and should be stored in a safe place out of the reach of children.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction).
• Severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa (severe dermatological reaction).
• Breathlessness or difficulty breathing, asthma attacks, respiratory distress with cough and fever (respiratory issues).
• Yellowing of the skin or eyes (jaundice), extreme lethargy (liver dysfunction).

Mild side effects

• Hypersensitivity: rash, anaphylaxis, thrombocytopenia, leukopenia, hemolytic anemia, positive antinuclear antibodies (ANA), increased erythrocyte sedimentation rate, vasculitis, lupus-like syndrome, photosensitivity, hypotension, angioedema, dermatomyositis, pruritus.
• Gastrointestinal: diarrhea, nausea, vomiting, constipation, abdominal pain, dyspepsia, stomatitis, heartburn, abdominal bloating, loss of appetite.
• Liver: ALT, AST, ALP, LDH, γ-GTP, total bilirubin.

This medication should be stored in a tightly sealed container to protect it from air and moisture. It should also be kept away from direct sunlight and stored at room temperature, avoiding too hot or cold places.

Appearance

This product is a white, round tablet.

Package unit

100 tablets (10 tablets/ PTP packaging x 10)