Difen Injection (Diclofenac Sodium)

Adult dosage

(Oral) As Diclofenac Sodium, the initial dosage is 100-150mg per day, and for maintenance or long-term use, 75-100mg per day divided into 2-3 doses. (Injection) As Diclofenac Sodium, administer 75mg (1 ampoule) as a deep intramuscular injection in one upper buttock once daily. In severe cases, administer 75mg each twice a day, alternating between both buttocks. After the initial phase of treatment, tablets should be considered.

Children's dosage

Administer 0.5-3mg per kg of body weight, divided into 2-3 doses daily. Adjust dosage based on age, condition, and symptoms.

This medication may cause gastrointestinal bleeding in individuals who regularly consume more than three alcoholic beverages per day, so consultation with a doctor or pharmacist is essential. This medication may affect the cardiovascular system and increase the risk of serious cardiovascular diseases such as myocardial infarction or stroke. Patients with cardiovascular diseases or risk factors need to be especially cautious and consult medical personnel immediately if symptoms occur. This medication can cause serious gastrointestinal adverse reactions such as gastrointestinal bleeding, ulcers, and perforation; therefore, it should be used with caution, especially in the elderly or patients with a history of gastrointestinal diseases. Severe allergic reactions may occur due to hypersensitivity, which could manifest as chest pain, so caution is warranted. The ampoule injection of this medication carries a risk of glass fragment contamination, so caution should be exercised during use, especially when administered to children or the elderly. Patients with a history of peptic ulcers, severe liver or kidney impairment, severe hypertension, heart failure, or who are allergic to any component of this medication should not use it. Patients with a history of peptic ulcers, liver or kidney function abnormalities, hypertension, heart failure, or asthma should use this medication cautiously and consult healthcare professionals immediately in case of adverse reactions. This medication may cause various adverse reactions, including but not limited to shock, gastrointestinal bleeding, blood disorders, rashes, liver or kidney impairment, and neurological disturbances. Symptoms should be reported immediately, and the medication should be discontinued. Long-term use necessitates regular blood tests, liver, and kidney function tests to check for abnormalities, and the duration of treatment and dosage should be limited to the shortest and minimal effective amount possible. The risk of adverse effects increases when used together with other non-steroidal anti-inflammatory drugs, so concurrent use should be avoided. There may also be interactions with specific medications, so patients should inform their healthcare providers about any other medications they are taking. During pregnancy, especially in the later stages, this medication may pose risks to the fetus, so it should be avoided. In breastfeeding mothers, it may cause adverse reactions in infants, and consideration should be given to stopping breastfeeding or the medication. Children and the elderly may have diminished temperature control capabilities, so greater caution should be exercised regarding adverse reactions when using this medication. In cases of overdose, symptoms may include hypotension, renal failure, seizures, and respiratory depression, and immediate emergency treatment should be sought if suspected.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rashes accompanied by high fever, blisters, skin shedding, pain in mucous membranes of the mouth/eyes, difficulty breathing or shortness of breath, asthma attacks, respiratory distress accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, thunderclap headache, seizures, confusion, visual disturbances, paralysis, and changes in urination.

Mild side effects

Itching, rash, increased blood pressure, decreased blood pressure, insomnia, depression, irritability, anxiety, diplopia, drowsiness, dizziness, neuroexcitability, confusion, hallucinations, seizures, tinnitus, dryness, superficial keratitis, epistaxis, oropharyngeal edema, interstitial pneumonia, frequent urination, nocturia, erectile dysfunction, vaginal bleeding, general malaise, sweating, thrombocytopenia, anemia, changes in platelet function, inhibition of platelet aggregation, impact on platelet function, symptoms of aseptic meningitis (headache, vomiting, etc.)

This medication can be susceptible to light; therefore, it should be stored in sealed containers that block light exposure. This will help maintain the efficacy of the medication for an extended period.

Appearance

A brown ampoule containing a colorless clear liquid

Package unit

50 ampoules [(2ml/ampoule) X 50]