Karomasteen Tablets 100 milligrams (Clotrimazole)

Adult use

Normally, 100 mg of clotrimazole is to be deeply inserted into the vagina once daily at bedtime for a continuous period of 6 days. For short-term therapy, 200 mg of clotrimazole is normally to be deeply inserted into the vagina once daily at bedtime for a continuous period of 3 days.

This medication should not be used by individuals who have had allergic reactions to the active ingredient or any of the constituents. During the use of this medication, it should not be used in conjunction with certain immunosuppressants such as tacrolimus or sirolimus, as these two medications can increase blood concentration and elevate the risk of side effects. If this medication must be taken together, careful monitoring by a physician and blood tests are necessary. Women who are pregnant or may become pregnant should consult a doctor before using this medication. Although animal studies have not revealed issues related to reproductive ability or teratogenesis, it is essential to follow the guidance of a professional for safety. During pregnancy, it is advisable to avoid the use of an insertion device while inserting the vaginal tablet. Women who are breastfeeding should also consult a doctor before using this medication. Since it acts locally and the amount absorbed systemically is small, the possibility of transferring through breast milk to the baby is low, but it is safe to seek professional advice. If unusual symptoms such as sudden allergic reactions, low blood pressure, difficulty breathing, abdominal pain, skin rashes, or vaginal bleeding occur while using this medication, it should be discontinued immediately and medical advice should be sought. It is advisable not to use this medication during menstruation, and additional drug treatment may be required for specific vaginal infections. Furthermore, attention should be paid to personal hygiene to prevent infection recurrence, and it is wise to avoid the use of tampons or vaginal cleansing products and abstain from sexual intercourse during treatment. This medication should be kept away from the eyes and must not be swallowed. In case of overdose, the risk of acute poisoning is low, but if suspected, one should visit a medical institution immediately. This medication may weaken rubber products such as latex condoms or intravaginal contraceptive diaphragms, so caution is necessary when using them together. This medication is for vaginal use only, and it is deemed safe for use by children over the age of 12 and adults only. When storing, keep it out of reach of children, and store it in its original container tightly closed. It should be kept in a cool place away from direct sunlight and with low humidity.

Serious side effects

• Vascular swelling
• hypersensitivity
• syncope
• hypotension
• difficulty breathing

Mild side effects

Abdominal pain, nausea, rash, urticaria, itching, vaginal peeling, vaginal discharge, vaginal bleeding, discomfort in the external genitalia, external genital erythema, burning sensation in the external genitalia, itching of the external genitalia, pain in the external genitalia, irritation at the site of application, swelling, pain

Drug interactions

Do not use this medication in conjunction with oral tacrolimus.

This medication may be sensitive to light, so it should be stored in a container that does not allow light to enter. It should also be kept in a sealed container that allows for minimal air exchange, and the storage temperature should be at normal room temperature, which is neither too hot nor too cold.

Appearance

It is a white, rectangular vaginal tablet.

Package unit

6 tablets/FOIL, 100 tablets/bottle