Medication info

Rethilon Injection (Diclofenac Sodium)

Prescription medication
Ingredient · strength
Diclofenac Sodium›37.5mg / 1mL
Manufacturer / importer
대화제약(주)
Appearance
Brown ampoules containing a colorless transparent liquid
Packaging
50 ampoules (2mL/ampoule x 50)
Approval status
Active

MFDS item code 198801647 · Notified 1988.08.22 · Insurance code 645600801

Summary

Main use
Relief of inflammation and pain in rheumatoid arthritis and osteoarthritis (degenerative joint disease), etc.
Who uses it
Adults · Children
Adult dosage
(Oral) The initial dose is 100-150mg per day, and in cases of relief or long-term administration, it is 75-100mg per day, divided into 2-3 doses. (Injection) Inject 75mg (1 ampoule) once daily deeply into one side of the upper buttock. In severe cases, 75mg can be administered twice daily, alternating between the left and right buttocks. After the initial treatment phase, conversion to tablets or suppositories is necessary.
Children's dosage
Administer 0.5-3mg per kg of body weight in 2-3 divided doses per day. Adjust as appropriate according to age, disease, and symptoms.

Ingredients

Manufacturer
대화제약(주)

Efficacy & effects

Relief of inflammation and pain in rheumatoid arthritis and osteoarthritis (degenerative joint disease), etc.

  • Rheumatoid arthritis
  • osteoarthritis
  • ankylosing spondylitis
  • inflammation
  • pain
  • acute gout
  • renal colic
  • hepatic colic
View approved original text

This medication is used to treat inflammation and pain caused by rheumatoid arthritis, osteoarthritis and other degenerative joint diseases, ankylosing spondylitis, post-surgical and post-traumatic inflammation and pain, acute gout, and pain around the kidneys and liver.

Dosage and Administration

Adult dosage

(Oral) The initial dose is 100-150mg per day, and in cases of relief or long-term administration, it is 75-100mg per day, divided into 2-3 doses. (Injection) Inject 75mg (1 ampoule) once daily deeply into one side of the upper buttock. In severe cases, 75mg can be administered twice daily, alternating between the left and right buttocks. After the initial treatment phase, conversion to tablets or suppositories is necessary.

Children's dosage

Administer 0.5-3mg per kg of body weight in 2-3 divided doses per day. Adjust as appropriate according to age, disease, and symptoms.

Precautions

This medication may increase the risk of gastric bleeding in individuals who regularly consume more than three glasses of alcohol daily, so consultation with a doctor or pharmacist is essential. This medication can cause cardiovascular problems; therefore, those with cardiovascular diseases or risk factors must be particularly cautious. If any cardiovascular symptoms occur while using this medication, immediate consultation with medical personnel is required. There is a risk of ulcers or bleeding in the stomach, so individuals with a history of gastrointestinal illness or the elderly should be particularly cautious. If symptoms of gastrointestinal bleeding occur during treatment, immediate medical treatment is necessary. This medication may cause severe chest pain as an allergic reaction, so those with a history of similar allergic reactions to medications should not take it. When using ampoule injections, care must be taken to avoid glass fragments, especially in children or the elderly, who require more caution. Individuals with peptic ulcers, severe blood disorders, markedly impaired liver or kidney function, severe hypertension or heart failure, and those allergic to any of the ingredients of this medication should not take it. Individuals who have previously experienced allergic reactions such as asthma or hives from this medication or similar drugs should also refrain from using it. While taking this medication, blood pressure, liver, and kidney function should be monitored regularly, and if abnormal symptoms arise, use should be halted immediately, and medical personnel should be consulted. It is advisable to avoid using this medication during pregnancy, especially in the later stages, as it may pose risks to the fetus. During breastfeeding, caution is needed as this medication can pass into breast milk and affect the baby. Children and the elderly should use the minimum dose cautiously, informing medical personnel of any adverse reactions that occur. Taking this medication with other nonsteroidal anti-inflammatory drugs may increase the risk of side effects, so co-administration should be avoided. Additionally, there may be interactions with specific medications, so if any other medications are being taken, medical personnel must be informed. In cases of overdose, symptoms such as hypotension, acute kidney failure, seizures, gastrointestinal disorders, or respiratory depression may occur, so if an overdose is suspected, immediate emergency treatment should be sought.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe rash with fever, blisters, peeling of skin, pain in mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Mild side effects

  • Peptic ulcer
  • gastric bleeding
  • esophageal ulcer
  • perforation
  • granulocytopenia
  • hemoglobin decrease
  • leukopenia
  • thrombocytopenia
  • anemia
  • aplastic anemia
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  • hemolytic anemia
  • bleeding tendency
  • allergic purpura
  • photosensitivity
  • erythema
  • itching
  • eczema
  • dermatitis
  • angioedema
  • polymorphous erythema
  • flushing
  • exudative dermatitis
  • hepatitis
  • liver dysfunction
  • GOT/GPT elevation
  • oliguria
  • hematuria
  • urinary protein
  • BUN
  • elevated serum creatinine
  • hyperkalemia
  • rash

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light and should be stored in a container that prevents light exposure. Additionally, it should be stored at room temperature, away from extreme heat or cold.

Appearance and packaging

Appearance

Brown ampoules containing a colorless transparent liquid

Package unit

50 ampoules (2mL/ampoule x 50)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.