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Key information summary
Efficacy & effects
Improvement of symptoms of depression.
Adult dosage
The initial dose of trazodone hydrochloride is 150 mg orally per day, increasing by 50 mg every 3 to 4 days. Outpatients should not exceed 400 mg per day, while inpatients (with severe depression) should not exceed 600 mg per day. Start with a low dose and gradually increase while monitoring for clinical response and intolerance. This medication must be taken after meals or snacks. For maintenance, the minimum effective dose should be administered.
Ingredients
Trazodone Hydrochloride
Rx / OTC
Prescription medication
Appearance
A hard capsule with a white to pale yellow powder inside, green upper part, white lower part.
Efficacy & effects
This medication is primarily used for the treatment of depression.
Dosage and Administration
The initial dose of trazodone hydrochloride is 150 mg orally per day, increasing by 50 mg every 3 to 4 days. Outpatients should not exceed 400 mg per day, while inpatients (with severe depression) should not exceed 600 mg per day. Start with a low dose and gradually increase while monitoring for clinical response and intolerance. This medication must be taken after meals or snacks. For maintenance, the minimum effective dose should be administered.
Precautions
Caution should be exercised when this medication is administered to children, adolescents, and young adults who have major depressive disorder or other psychiatric conditions, as there may be an increased risk of suicidal thoughts or behaviors. During administration, patients should be monitored closely, and if any abnormal behavioral changes such as suicidal tendencies or aggression occur, medical personnel should be consulted immediately. This medication can cause a serious side effect known as priapism, and if such symptoms arise, the medication should be discontinued immediately and a doctor should be consulted. This medication should never be administered to individuals who have an allergy to the drug or its components, or those who are taking certain medications, particularly in combination with MAO inhibitors, due to the associated risks. Special caution is needed for patients with certain conditions such as heart disease, glaucoma, seizure disorders, and bipolar disorder, and care should also be taken with elderly patients or those with compromised kidney and liver function. This medication may cause drowsiness or reduced concentration, necessitating caution when driving or operating hazardous machinery. During treatment, signs of side effects should be monitored through blood tests, and if abnormal symptoms occur, treatment should be discontinued immediately and medical personnel informed. Women who are pregnant or breastfeeding should exercise caution when using this medication, and breastfeeding should be avoided or discontinued if possible while on this medication. Safety and efficacy in individuals under 18 years of age have not been established, so this medication is not used in this age group. In cases of overdose, serious side effects may occur, so the prescribed dosage and regimen must be strictly adhered to, and if any abnormal symptoms appear, immediate medical attention should be sought. This medication should be stored out of reach of children, and it is important to avoid transferring it to other containers to ensure safety and quality.
Side effects
Urticaria, severe swelling (edema), severe allergic reactions, severe rashes with high fever, blisters, skin peeling, pain in the oral/ocular mucosa, severe skin adverse reactions, difficulty breathing, respiratory issues, yellowing of the skin or eyes (jaundice), liver issues (jaundice), sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, severe neurological symptoms, markedly reduced urine output, systemic reactions.
