Pentoxin Sustained Release Tablets 400 mg (Pentoxifylline)

Adult dosage

(Oral: tablets) Adults: Administer 400㎎ of pentoxifylline per dose orally 2-3 times daily after meals with a small amount of fluid. The dose may be adjusted as appropriate depending on age and symptoms. (Injection) 1. Intravenous injection: Adults: Inject 100㎎ of pentoxifylline per day. Keep the patient lying down and administer slowly by intravenous injection over at least 5 minutes, or by intra-arterial injection if necessary. To assess the patient's individual response, it is preferable to initially administer 50㎎ diluted with normal saline injection to a volume of 10㎖. 2. Intravenous infusion: Initially, mix 100㎎ per day with 250-500㎖ of an infusion solution (such as normal saline injection or 5% fructose injection) and administer by intravenous infusion over 90-180 minutes. Starting the next day, increase the dose by 50㎎ daily until the daily dose reaches 300㎎. In cases of severe circulatory impairment, administer twice daily. 3. Intra-arterial injection: Using a motor-driven syringe, mix 100-300㎎ per day with 20-50㎖ of normal saline injection and inject slowly at a rate of 10㎎/min. 4. Tablets 100-200㎎ may be administered as adjunctive therapy to intravenous injection or intravenous infusion. After symptoms improve, treatment may be continued by oral administration. The dose may be adjusted as appropriate depending on age and symptoms.

This medication is a methylxanthine derivative and should not be administered to patients with a history of hypersensitivity to this drug or similar medications. It should also be avoided in patients with acute myocardial infarction, massive hemorrhage, or extensive retinal hemorrhage, and should not be used in conjunction with the specific anti-inflammatory drug ketorolac. It should be administered cautiously in patients with severe deep vein disease, hypotension, coronary artery disease, severely impaired kidney function, severely impaired liver function, or increased bleeding tendencies. This medication can cause allergic reactions such as skin rashes, itching, urticaria, and in rare cases, severe anaphylactic reactions, so usage should be discontinued immediately if symptoms occur, and a physician should be consulted. Gastrointestinal side effects may include loss of appetite, nausea, vomiting, abdominal pain, and diarrhea, while cardiovascular symptoms may include dyspnea, edema, and cardiac-related symptoms. Blood abnormalities such as liver function anomalies, bleeding, or thrombocytopenia may rarely occur, so any abnormal symptoms should be reported immediately. Neurological symptoms may include headaches, dizziness, insomnia, anxiety, and respiratory tract symptoms such as nosebleeds or nasal congestion have been reported. High-dose administration may lead to more frequent gastrointestinal disturbances and arrhythmias. In patients with cerebrovascular diseases, it should only be used after a precise diagnosis, and hypertension patients must have their blood pressure monitored regularly during administration. This medication may interact with anticoagulants, antiplatelet agents, insulin, hypoglycemic agents, and antihypertensive drugs, so caution is required when taken together. Safety has not been established in pregnant or potentially pregnant women and breastfeeding women, so it is advisable to avoid administration. There has been no experience using it in children, and in elderly patients, where bodily functions are often reduced, it should be administered cautiously with observation. There is no specific antidote for overdose, so measures such as gastric lavage or administering activated charcoal should be taken to prevent absorption of the drug. Store this medication out of the reach of children and do not transfer it to other containers for safety.

• Itching
• skin redness
• hives
• angioedema
• bronchospasm
• shock
• loss of appetite
• nausea
• vomiting
• gastric discomfort

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Additionally, it is best to store the medication at room temperature that is not too hot or too cold.

Appearance

White, oval film-coated tablet

Package unit

30 tablets/bottle, 500 tablets/bottle