Quran Injection 50 mg (Ranitidine Hydrochloride)

Adult dosage

As ranitidine, administer 50 mg intravenously or intramuscularly 3-4 times daily. For intravenous administration, dilute 50 mg in 20 mL of normal saline or dextrose solution and administer slowly over at least 2 minutes, or mix it in IV fluid and administer as a continuous intravenous drip at a rate of 25 mg/hr over 2 hours. For pre-anesthetic medication (to prevent Mendelson's syndrome), administer 50 mg intramuscularly or slowly intravenously over 1 minute 45-60 minutes before anesthesia onset.

Children's dosage

Clinical studies for pediatric use have not been established.

This medication should be opened carefully as it comes in glass ampoules to prevent glass fragments from mixing in, especially with children and the elderly. It should not be used in patients with a history of allergic reactions to this drug or its components. In patients with impaired kidney function, the drug may remain in the body for an extended period, thus the dosage should be reduced or the dosing interval extended. Patients with poor liver function, a history of drug allergies, the elderly, and those with acute porphyria should use this medication with caution. While using this medication, severe allergic reactions, blood disorders, liver dysfunction, irregular heartbeats, gastrointestinal issues, or neurological symptoms may occur; if any unusual symptoms arise, discontinue use and seek medical attention immediately. It is vital to monitor the patient's condition regularly and perform blood tests, liver function tests, and kidney function tests during treatment. Elderly patients or those with chronic diseases may be at increased risk of pneumonia, so caution is warranted. If this medication is to be injected intravenously for more than five days, there is a possibility of elevated liver enzyme levels, so daily liver function tests are recommended. If oral administration is possible, it is advised to switch to oral medication as soon as feasible. This medication may interact with other drugs, so it is essential to inform the doctor or pharmacist if other medications are being taken, especially when used with anticoagulants, as there may be an increased risk of bleeding. Women who are pregnant or may become pregnant, as well as nursing women, should carefully weigh the risks and benefits of using this medication. The safety of this drug in children has not been adequately established, thus caution is advised. In cases of overdose, gastric emptying treatment should be received along with appropriate symptomatic treatment, and blood dialysis may be performed if necessary. When administrating the injection, pain or hardness at the injection site may occur, and there is a risk of irregular heartbeats; therefore, the injection should be administered slowly. This medication may mask the symptoms of stomach cancer, so patients with gastric ulcers or newly developed dyspepsia who are middle-aged or older should be checked for malignancy before use. Long-term use may affect eye health, so regular ophthalmological examinations are necessary.

Serious side effects

• Hives
• angioedema
• anaphylactic shock
• chest pain
• hypotension
• vascular edema
• bone marrow suppression
• aplastic anemia
• agranulocytosis
• pancytopenia

Mild side effects

Rash, fever, angioedema, hypotension, chest pain, vascular edema, granulocytopenia, elevated serum creatinine levels, leukopenia, thrombocytopenia, liver function impairment (increased AST, ALT, γ-GTP, ALP levels), bradycardia, atrioventricular block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal distension, abdominal pain, loss of appetite, diarrhea, dizziness, drowsiness, headache, heaviness in the head, insomnia, agitation, anxiety, confusional state, depression, hallucination.

This medication should be stored in a cool place below 30 degrees Celsius, protected from light in a sealed container, to maintain its efficacy for a longer period.

Appearance

A clear liquid that is colorless to light yellow in color, packaged in brown ampoules.

Package unit

50 ampoules/box [(2 mL/ampoule)]