Tamadol Injection (Tramadol Hydrochloride)

Adult administration

Administer 50-100mg of tramadol hydrochloride by intravenous injection or intramuscular injection, and repeat as needed every 4-5 hours. The maximum daily dose can be up to 400mg.

This drug should be used with caution as seizures may occur if the recommended dose is exceeded. Careful use is necessary, especially for patients at risk of seizures or those with epilepsy, and should only be used when needed. Long-term use of this medication may lead to psychological and physical dependence; thus, it should be administered for a short duration under strict supervision to patients at risk of abuse. When combined with central nervous system depressants or alcohol, severe sedation, respiratory depression, or coma may occur, requiring caution when used together. Patients with specific genetic traits that cause the drug to metabolize more quickly are at higher risk for respiratory depression, necessitating dosage adjustment and monitoring. This medication should not be administered to children under 12 years old or adolescents under 18 years old who have undergone tonsillectomy or adenoidectomy. Even when administration is necessary in this age group, it must be done with extreme caution. Care should be taken when using ampoule injections, as glass fragments may mix in when the container is cut, especially when administering to children or the elderly. This medication should not be administered to patients with acute alcohol intoxication, central nervous system drug intoxication, severe respiratory depression, head injury, those taking MAO inhibitors, severe renal or liver dysfunction, pregnant or nursing women, or those with specific hypersensitivity. Furthermore, caution is necessary when administering to patients taking morphine, with bile duct diseases, liver dysfunction, drinking patients, kidney disease patients, those taking central nervous system depressants, or those with a history of seizures. Drowsiness and dizziness may occur during administration; therefore, driving or operating dangerous machinery should be avoided, and careful judgment is necessary in patients with acute abdominal diseases. In cases of overdose, severe respiratory depression and seizures may appear, requiring immediate emergency treatment, and naloxone may be used as an antidote. This medication has various drug interactions, so consult a specialist when combined with other drugs, especially central nervous system depressants, MAO inhibitors, and antidepressants. It is safest not to use this medication during pregnancy or lactation, as it may be transferred to the baby through breast milk and potentially pose a risk. Elderly patients may have increased blood concentrations, thus dosages should be limited, and doses above 300mg per day should be avoided for those over 75 years old. Patients receiving this medication should fully discuss treatment goals and discontinuation plans with healthcare providers and should be carefully monitored for dependence and abuse risks.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, severe dermatological reactions, difficulty breathing, asthma attacks, respiratory difficulties accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities, sudden and severe headaches, lightning headaches, seizures, confusion, visual disturbances.

Mild side effects

• Drowsiness
• dizziness
• staggering
• nausea
• vomiting
• abdominal distension
• abdominal discomfort
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a sealed container to prevent air and moisture from entering. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. This storage method helps preserve the drug's effectiveness and safety for longer.

Appearance

A colorless, transparent ampoule containing a colorless, transparent liquid.

Package unit

50 ampoules [(1mL/ampoule) X 50]