Glucanil Tablets (Metformin Hydrochloride)

Adult dose

The dosing regimen should be individualized based on the drug's efficacy and tolerability, and it should not exceed the recommended maximum daily dose. This medication should be started at a low dose to reduce gastrointestinal side effects and ascertain the minimum effective dose necessary for adequate blood sugar control, with administration of 500 mg 2 to 3 times daily with meals. The dose may be increased gradually by 500 mg each week, up to 20

Child dose

This medication can be used in children aged 10 years and older. The general starting dose is 500 mg once daily taken during or after meals. Blood sugar levels should be measured after one week to adjust the dosage.

This medication helps in controlling blood sugar and is primarily used in patients with type 2 diabetes. Caution should be exercised as serious side effects such as severe lactic acidosis or hypoglycemia may occur during treatment. Lactic acidosis, although rare, can be a life-threatening condition characterized by abnormally high levels of lactic acid in the blood and decreased blood acidity. Patients with moderate to severe renal impairment or acute kidney injury should not take this medication. Additionally, patients with acute myocardial infarction, heart failure, serious infections, or dehydration should avoid its use. This medication should be temporarily discontinued before and after tests involving iodinated contrast media, and it should only be restarted once renal function is confirmed as normal. Patients who have had an allergic reaction to this medication or similar medications should not take it, and it is also not indicated for patients with type 1 diabetes or a history of ketoacidosis. The medication should be stopped within 48 hours prior to surgery and may be resumed once kidney function is confirmed as normal post-surgery. Side effects may include gastrointestinal disturbances, metallic taste, rash, anemia, liver function abnormalities, and hypoglycemia, with gastrointestinal symptoms being particularly common during the initial treatment phase. These symptoms usually dissipate over time; however, if they become severe, medical advice should be sought. Regular monitoring of kidney function is necessary, and the medication should be discontinued if there is a deterioration in renal function. Excessive alcohol consumption should be avoided as it may increase the risk of lactic acidosis. Periodic checks on blood sugar control should be performed, and in cases of sudden health changes, infections, or surgeries, medication adjustments may be necessary in consultation with a healthcare professional. This medication may interact with other drugs, so it is essential to inform healthcare providers of any other medications being taken, especially hypoglycemic agents, diuretics, antihypertensives, and certain antibiotics. During pregnancy, the effects on the fetus have not been fully elucidated; therefore, women who are pregnant or planning to become pregnant should consult a doctor before use. If breastfeeding, caution is advised as this medication may be excreted in breast milk and could potentially affect the newborn, requiring a careful decision on whether to continue breastfeeding or discontinue the medication. Elderly patients may have a higher likelihood of decreased renal function, therefore appropriate dose adjustments and regular kidney function tests are necessary. In case of overdose, hypoglycemia is not typically induced; however, accumulation of the medication in the body may occur, warranting immediate medical treatment, and dialysis may be helpful. This medication can assist in controlling blood sugar levels without weight gain, and it is important to maintain a consistent diet and exercise routine while taking it. Lastly, this medication should be kept out of reach of children, and it is advisable not to transfer it to another container.

Serious side effects

Lactic acidosis (associated with acute renal failure, cardiopulmonary disease, sepsis), severe allergic reactions (such as rash), liver dysfunction (liver function abnormalities), hypoglycemia, acute renal failure, elevated blood pressure and severe edema, severe neurological symptoms, respiratory issues

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, hypoglycemia, delayed hypoglycemia

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. The recommended storage temperature is room temperature between 1 degree and 30 degrees Celsius. This ensures the medication's efficacy and safety are maintained for an extended period.

Appearance

White round film-coated tablet

Package unit

500 tablets/bottle