Altamin Capsule 250 milligrams (D-Penicillamine)

Adult dose

1. Wilson's disease ○Adults: Administer 1g of D-penicillamine per day orally in 4 divided doses (30 minutes before meals or 3 hours after the evening meal). 2. Lead or mercury poisoning ○Adults: Administer 250mg of D-penicillamine per dose orally 3-4 times daily (30 minutes before meals or 3 hours after the evening meal). 3. Cystinuria, cystine stones ○Adults: Administer 1-4g of D-penicillamine per day in 4 divided doses (30 minutes before meals or 3 hours after the evening meal). Start with an initial dose of 250mg per day and gradually increase to the required dose. 4. Rheumatoid arthritis, chronic active hepatitis, scleroderma Weeks 1-4: Administer 150mg per dose orally once daily (maximum 250mg per day). Weeks 5-8: Administer 250mg per dose orally once daily (maximum 450mg per day). Weeks 9-12: Administer 150mg per dose orally twice daily (maximum 600mg per day). Week 13 onward: Increase the daily dose by 50-150mg at intervals of 4-12 weeks, up to 750mg per day. Depending on symptoms, the dose may be increased to 1g per day. When clinical improvement is evident, gradually reduce the dose by 50-150mg to maintain the minimum effective dose. The usual maintenance dose is 300-450mg per day. Discontinue this drug if symptoms do not improve.

Child dose

1. Wilson's disease ○Children: Gradually increase the dose to 20mg per kg of body weight per day, divide it into doses, and administer before meals. 2. Lead or mercury poisoning ○Children: Administer 20-30mg per kg of body weight per day in several divided doses. 3. Cystinuria, cystine stones ○Children: Administer 30mg per kg of body weight per day in 3-4 divided doses. 5. Juvenile rheumatoid arthritis Start treatment at a dose of 5-10mg per kg of body weight per day. Gradually increase the dose to 15-20mg per kg of body weight per day. When clinical improvement is evident, reduce the dose to the maintenance dose of 10-15mg per kg of body weight.

This medication may cause serious blood disorders, so extreme caution is required during use. Symptoms like agranulocytosis may occur, and any symptoms should prompt immediate consultation with a physician. It should not be administered to patients on gold compounds, those with a history of blood disorders, or patients with renal dysfunction. Additionally, patients with systemic lupus erythematosus, children in growth phases, chronic lead poisoning patients, and those taking specific medications should avoid using this medication for safety. Caution is also needed for women who are pregnant or may become pregnant, nursing mothers, the elderly, patients shortly after surgery, or those with impaired bone marrow function. Patients with liver dysfunction or hypersensitivity to penicillin-type drugs also require caution. While taking this medication, regular blood tests and assessments for kidney and liver function are necessary; if any abnormal symptoms arise, use should be discontinued immediately, following the physician's instructions. Various side effects can occur across the gastrointestinal, respiratory, skin, and nervous systems, so attention should be paid to symptoms. In particular, if pulmonary symptoms or severe allergic reactions appear, healthcare providers should be notified immediately. This medication can interact with other drugs, so it is essential to consult a doctor or pharmacist when taking it with gold compounds, immunosuppressants, iron preparations, antacids, zinc supplements, etc. Pregnant or breastfeeding women should generally not use this medication; if it must be used, breastfeeding should be discontinued. Special caution is required when administering to children or the elderly, and it should only be used when the therapeutic benefits outweigh the risks.

• Thrombocytopenia
• leukopenia
• anemia
• nephrotic syndrome
• pancytopenia
• aplastic anemia
• neutropenia
• agranulocytosis
• monocytosis
• leukocytosis

This medication may be sensitive to air or moisture; therefore, it is important to store it in a sealed container. This helps maintain the medication's efficacy and prevents degradation.

Appearance

White powder contained in hard capsules, upper and lower white

Package unit

30 capsules/bottle