Kujuspirodactone (Spironolactone)

Adult dose

Spironolactone is administered orally in divided doses of 50-100 mg per day. When used as a diuretic, it is best to combine it with other diuretics, and the dosage should be reduced gradually over 2-3 days when stopping. Adjust doses appropriately according to age and symptoms.

This medication should only be used for specific diseases and should not be used unnecessarily. Taking it together with medications or foods high in potassium may lead to dangerously high potassium levels in the blood, so these should not be taken simultaneously. Patients with poor liver function should be cautious when using this medication as it may disrupt fluid and electrolyte balance, leading to severe brain dysfunction. Co-administration with lithium can reduce lithium excretion, increasing the risk of toxicity; therefore, it is advisable not to use them together. Patients with severe heart failure may experience dangerously high potassium levels due to this medication, so potassium levels should be monitored regularly through blood tests. This medication should not be used in patients with severely impaired kidney function or those who do not urinate at all, patients with significantly reduced liver function, patients with hyperkalemia, patients allergic to this medication, and patients with Addison's disease. Patients with severe atherosclerosis or cerebrovascular atherosclerosis, patients with weak liver or kidney function, patients on a restricted sodium diet, and infants should use this medication with caution. This medication may cause various side effects, including leg cramps, electrolyte imbalance, gynecomastia, skin rashes, gastrointestinal disturbances, dizziness, headaches, and blood abnormalities; any unusual symptoms should be reported to a doctor immediately. Long-term use may lead to electrolyte imbalances, so regular blood tests are necessary, and when hyperkalemia is suspected, an electrocardiogram should be performed to check heart condition. When taking it with other antihypertensives, blood pressure may drop too low, so care should be taken with dosage adjustments, and special precautions are needed during anesthesia. This medication may affect the fetus during pregnancy, so it is best to avoid use during this period, and during breastfeeding, it should be avoided or discontinued as it can be passed through breast milk. Safety in children has not been established, so it should be used with caution in pediatric patients. Elderly patients may develop dehydration or low blood pressure due to rapid diuresis, so treatment should start at a low dose, observing their condition closely. In case of overdose, emergency measures such as inducing vomiting or gastric lavage may be required, and professional treatment may be necessary for severe hyperkalemia. This medication is usually taken in the morning, and patients who need rest at night should ideally take it in the morning to reduce discomfort from urination.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/eye mucosa, difficulty or shortness of breath, asthma attacks, respiratory distress accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme drowsiness, sudden and severe headaches, lightning headaches, seizures, confusion, visual disturbances, paralysis, significantly decreased urine output

Mild side effects

• Leg cramps
• hyponatremia
• metabolic acidosis
• BUN increase
• gynecomastia
• breast swelling
• breast pain
• decreased libido
• erectile dysfunction
• hirsutism

This medication may be sensitive to light, so it should be stored in a light-resistant container. It should also be kept in a sealed container to prevent air exposure to maintain its efficacy.

Appearance

Yellowish round film-coated tablet

Package unit

For domestic use: 300 tablets/bottle For export: 30 tablets (PTP packaging)