Hwanin Hydantoin Tablet (Phenytoin)

Adult dosage

The dose should be adjusted according to the severity of seizures and the patient's tolerability; measure the blood concentration if necessary. This drug must not be administered once daily and must be given in divided doses. Adults: Administer 100 mg of phenytoin orally 3 times daily; the maintenance dose is 300 ～ 400 mg of this drug in divided doses. The daily dose may be increased to 600 mg of this drug. Adults: Slowly administer 125 ～ 250 mg of phenytoin sodium by intravenous injection at a rate not exceeding 50 mg/min. If seizures are not controlled with this dose, administer an additional 100 ～ 150 mg of this drug after 30 minutes or consider other treatment. When convulsions have stopped and consciousness has returned following administration of this drug, switch to oral administration. Adults: As the initial dose, administer 3.5 ～ 5 mg of phenytoin sodium per kg of body weight by intravenous injection. Repeat once if necessary. This drug must be administered slowly by intravenous injection at a steady rate not exceeding 50 mg/min. Adjust the dose appropriately according to age and symptoms.

Children's dosage

Administer 5 mg of phenytoin per kg of body weight in 2 ～ 3 divided doses; the maintenance dose is 4 ～ 8 mg of this drug per kg of body weight per day in divided doses. Up to 300 mg of this drug may be administered daily.

This medication is used for the treatment of epilepsy. There is a risk of mood changes, such as suicidal thoughts or behavior, and depression during treatment, so patients and caregivers should closely monitor for these symptoms. When administered as an injection, there may be inflammation or tissue damage at the injection site, and in severe cases, skin necrosis or pain may occur, requiring caution. Patients with allergies to this medication or its components, as well as those with cardiac issues or blood disorders, should not be administered this drug. Patients with impaired liver or kidney function, heart diseases, diabetes, hypothyroidism, etc., should use this medication with caution, and any skin rashes or unusual symptoms should be reported to a physician immediately. Psychiatric side effects such as dizziness, movement disorders, and insomnia may occur, and in severe instances, neurological symptoms can develop, necessitating vigilance. This medication can affect multiple organs, including the liver, blood, skin, kidneys, and eyes, so regular check-ups are required. Furthermore, due to the high potential for drug interactions, it is imperative to inform healthcare professionals about any concomitant medications. During pregnancy, there is a risk of causing malformations or developmental disorders in the fetus, so women planning to conceive should consult before taking this medication, and its use during pregnancy should be avoided whenever possible. In the elderly, the side effects may be more severe due to decreased body function, necessitating starting with low doses and gradually tapering. In cases of overdose, central nervous system symptoms along with respiratory or blood pressure reduction may occur, requiring immediate emergency treatment. This medication should be stored in a safe place out of the reach of children and should not be transferred to another container. Lastly, during the use of this medication, drowsiness or decreased concentration may occur, thus avoiding driving or operating dangerous machinery is advisable.

Suicidal impulse, suicidal behavior, depression, abnormal changes in mood and behavior, soft tissue irritation, inflammatory response, extravasation, Purple Glove syndrome, edema, skin discoloration, pain distal to the injection site, necrosis, skin shedding, pain at the injection site, abscess, involuntary movements, dyskinesia, chorea, fixed posture inability, neuropathy, dizziness, ataxia, mental confusion, dysarthria, insomnia, neuroexcitability, decreased attention, decreased concentration, decreased reflex motor ability, headache, fatigue, disharmony, tremors, sensory peripheral polyneuropathy, interstitial pneumonia, skin-mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, systemic lupus erythematosus-like symptoms, urticaria, eosinophilia, drug reaction (DRESS), fever, rash, lymphadenopathy, facial edema, hepatitis, nephritis, hematological disorders, myocarditis, myositis, hypersensitivity reaction, scarlet fever-like rash, measles-like rash, toxic dermal rash, aplastic anemia, thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, pancytopenia, erythrocytosis, aplastic anemia with red blood cell characteristics, hypoplastic anemia, monocytic leukemia, hemolytic anemia, lymph node swelling, lymphoma, pseudolymphoma, lymphadenopathy resembling Hodgkin's disease, toxic hepatitis, jaundice, proteinuria, diplopia, nystagmus, visual impairment, cataract, gingival hyperplasia, facial disturbances, hypertrichosis, lip swelling, Peyronie's disease, nausea, vomiting, constipation, nodular periarteritis, polyarthritis, hyperglycemia, fever, abnormal thyroid function test results, polydipsia, vascular pain, cardiovascular collapse, cardiac arrest, ventricular fibrillation, respiratory arrest, tonic-clonic seizure, decreased bone density, osteopenia, osteoporosis, fracture, nystagmus, ataxia, severe hypertonia, somnolence, speech disorder, coma, hypotension, respiratory distress, vascular system suppression

This medication is sensitive to light and should be stored in a container that does not allow light to enter. Additionally, it is vital to store it at a cool room temperature, specifically between 1 to 30 degrees Celsius, to maintain its efficacy.

Appearance

This is a white, round tablet.

Package unit

Domestic use - 300 tablets/bottle, export use - 30 tablets/box [10 tablets/PTP x 3]