Sodium Chloride and Dextrose Injection(1-3)

Adult administration

Typically, for adults, a single dose of 500–1,000mL is administered via intravenous drip. The infusion rate is 300–500mL per hour (75–120 drops per minute).

Child administration

In children, the administration rate is 50–100mL per hour. Especially, in neonates and premature infants, a rapid infusion (more than 100mL per hour) should not be performed.

This medication contains dextrose, which may increase the consumption of thiamine (vitamin B1) in the body during intravenous administration. Therefore, there is a risk of sudden, potentially fatal thiamine deficiency, so caution is required. This medication should not be administered to patients with excessive fluid status or storage dehydration, or hypokalemia. Care should be taken when administering this medication to patients with renal impairment due to kidney disease, heart failure, hypertonic dehydration, reduced urine output due to obstructive uropathy, diabetes mellitus, or hyperchloremia. Rapid or large volume administration of this medication may cause side effects such as cerebral edema, pulmonary edema, peripheral edema, acidosis, and water intoxication. The risk of water intoxication is particularly higher in neonates and premature infants. Additionally, thrombosis may occur at the intravenous injection site, so caution is necessary. During administration, blood glucose, serum electrolytes, and fluid balance should be regularly monitored to ensure no abnormalities. The safety of this medication during pregnancy has not been completely established, and it should be administered only after careful consideration of the risks to the fetus and therapeutic effects. Administering dextrose-containing solutions during labor may lead to metabolic abnormalities such as hyperglycemia or hypoglycemia in both the mother and fetus, so caution is required. Newborns, especially preterm or low-birth-weight infants, face a high risk of hypoglycemia or hyperglycemia due to difficulty in blood sugar control, so close observation and management are necessary. Care should be taken not to administer rapidly or for prolonged periods in infants and the elderly, and in the elderly, it should be administered more cautiously to prevent circulatory overload in those with heart failure or renal failure. In cases of overdose, diuretics should be used to manage the body's fluid and electrolyte balance. Before administration, the patient's infection status should be checked and the skin and infusion equipment should be thoroughly disinfected. During cold conditions, the medication should be warmed to body temperature before use, and any remaining medication should be discarded immediately after opening. Administration should be done slowly via intravenous infusion to reduce the risk of side effects. Care should be taken to avoid air entering the infusion container, and continuous connections should be made to prevent the risk of air embolism. Finally, this medication should be stored at room temperature, and care should be taken regarding temperature changes during storage.

Serious side effects

Peripheral edema (severe swelling of the entire body)

Mild side effects

• Cerebral edema
• pulmonary edema
• peripheral edema
• acidosis
• water intoxication
• thrombosis

This medication should be stored in a sealed container to prevent air or moisture from entering, and it is best to store it at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the efficacy of the medication.

Appearance

This medication is a colorless, transparent solution with a slight salty and sweet taste, filled in colorless transparent glass or plastic containers.

Package unit

500mL/pack