Dae Han Epinephrine Injection Solution

Adult administration

As a 0.1% injection solution, 0.2-1.0 mL is administered subcutaneously and intramuscularly at one time. In cases of emergency such as cardiac arrest, it should be diluted within a range not exceeding 0.25 mL with normal saline injection and administered slowly intravenously. Add 1-2 drops of this medication to 10 mL of local anesthetic for use.

This medication should be used cautiously as there is a risk of glass fragments may enter when opening the ampoule, and extra care should be taken especially when used in children and the elderly. This medication has a vasoconstrictive effect, so it should not be administered to patients with certain conditions such as atherosclerosis, heart disease, and hypertension. In addition, it should be administered cautiously to patients with various conditions such as thyroid dysfunction, diabetes, glaucoma, pneumonia, and in pregnant women, pediatric patients, and the elderly as they may require careful monitoring. Severe side effects such as abnormal heart rhythms or elevated blood pressure may occur upon administration, so cardiac conditions should be carefully monitored. If adverse symptoms such as hypersensitivity reactions, breathing difficulties, headaches, or vomiting occur, administration should be stopped immediately and appropriate treatment sought. This medication may interact with other drugs; therefore, if the patient is currently taking any medications, it is essential to inform the healthcare provider, especially when combined with specific antidepressants, antipsychotics, and antihypertensive agents. Pregnant or breastfeeding women are advised to avoid use as it may affect the fetus or newborn. Children and the elderly may be sensitive to this medication, so starting with a lower dose and close monitoring of their condition is recommended. In case of overdose, serious cardiovascular complications may arise, requiring immediate medical attention, and specific blockers or vasodilators may be administered if necessary. This medication should not be mixed with other injection solutions, and care should be taken to check the injection site frequently to prevent local necrosis if the substance seeps out.

Serious side effects

Pallor, chest tightness, prodromal symptoms of hypersensitivity (itching, urticaria, swelling of lips and oral cavity, diaphoresis, hypotension), cardiac arrest, ventricular fibrillation, rapid elevation of blood pressure, cerebrovascular hemorrhage due to severe hypertension, pulmonary edema, breathing difficulties, ventricular rhythm disturbances, cardiac arrhythmias, ventricular fibrillation, pulmonary edema, cerebrovascular hemorrhage, renal function failure, ventricular fibrillation, severe edema or urination abnormalities, severe neurological symptoms (possible headache, dizziness, confusion of consciousness).

Mild side effects

Palpitations, myocardial ischemia, stress-induced cardiomyopathy, chest pain, tachycardia, arrhythmias, flushing, elevated blood pressure, headache, dizziness, anxiety, tremors, memory impairment, psychomotor agitation, nausea, vomiting, pigmentation with ophthalmic and subconjunctival injection, conjunctival hyperemia, ocular pain, corneal pigmentation with prolonged use, local injection site necrosis, peripheral ischemia, heat sensation, sweating, cold extremities, hypersensitivity, hyperglycemia, gastrointestinal and renal/myocardial necrosis.

This medication is sensitive to light, so it should be stored in a sealed container that does not allow light in. Additionally, the storage temperature should be kept below 25 degrees Celsius, and it should not be stored in a refrigerator to avoid chilling.

Appearance

A colorless, transparent solution contained in a brown ampoule injection.

Package unit

0.1% 1 milliliter × 10 ampoules (for export), 50 ampoules (for domestic use)