Korea Dextrose Injection (20%)

Adult administration

Administer intravenously in a single dose of 20~500 mL. The intravenous infusion rate should be less than 0.5g/kg per hour as glucose. Use an appropriate amount for the dilution of the injection. Adjust the amount reasonably according to age and symptoms.

When using this medication in ampoule form, there is a risk of glass fragments mixing in, so it is important to handle the ampoule carefully, especially when administering to children or the elderly. Patients receiving intravenous injections of this medication that contains glucose are at risk of vitamin B1 deficiency, necessitating caution. This medication should not be used in individuals with specific conditions such as storage dehydration, excess fluid state, hyperglycemia, acidosis, hypokalemia, hyperosmolar coma, glucose intolerance, anuria, or hepatic coma. This medication’s hypertonic solution is not administered to patients with intratulbar or intracranial hemorrhage, and hypertonic glucose solutions should also be avoided in severely dehydrated patients. Caution should be exercised when administering to patients with deficiencies in potassium, phosphate, magnesium, or those with hyponatremia, diabetes insipidus, renal failure, heart failure, thiamine deficiency, sepsis, or critically ill patients. Rapid or excessive administration of this medication may lead to electrolyte imbalances or fluid overload, hence the rate and amount of administration should be carefully controlled. In case of excessive dosing, blood bilirubin and lactate levels may rise, and side effects such as hypokalemia, hyperosmolar coma, acidosis, dehydration, and hyperosmolarity can occur. During intravenous injection, fluid imbalance, congestion, pulmonary edema, and pain or inflammation at the injection site or thromboembolism may occur, requiring careful monitoring. Long-term use may affect insulin secretion, and insulin therapy may be necessary. In situations requiring blood glucose control, blood glucose and electrolyte levels should be checked frequently, and attention should also be given to fluid balance. During pregnancy, the effects on the fetus are not clearly understood, so administration should only be done when absolutely necessary, and blood glucose levels of the mother and newborn should be closely monitored when given during labor. Children and neonates may have impaired ability to manage fluids and electrolytes, so blood glucose and electrolyte concentrations must be monitored closely, especially adjusting the rate of administration for low birth weight infants. Elderly patients may have decreased body function, so this medication should be used cautiously. In cases of overdose, hyperglycemia and diabetes symptoms may develop and require management with insulin. Subcutaneous injections may cause local irritations and circulatory failure, so it is recommended to avoid them; opened medication should be used immediately and any remaining should be discarded. During injection, precautions should be taken against infection, and it is advisable to warm the medication to body temperature before administration. When using with other medications, careful monitoring is required due to the potential for chemical interactions and adverse reactions. Additionally, to reduce the risk of air embolism from residual air in the container, continuous connection for use is not recommended.

Mild side effects

Hypokalemia, acidosis, dehydration, hyperosmolarity, polyuria with glucose detection, thrombosis, extravasation, injection site pain, uremia, fever, phlebitis, fluid-electrolyte imbalance, congestion, pulmonary edema, hyperglycemia, renal loss, serum electrolyte imbalance, hypoglycemia, hyperglycemia, local irritation, thrombophlebitis, agglutination reactions, potential adverse reactions when administered simultaneously with blood, risk of air embolism

This medication should be stored in a sealed container to prevent air or moisture ingress, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. Maintaining the proper storage temperature preserves the medication's efficacy and prevents degradation.

Appearance

A colorless, transparent liquid containing a sweet taste, filled in a colorless, transparent ampoule or a plastic (polypropylene or polyethylene) aqueous injection container

Package unit

20mL/ampoule × 50