Rinarem Extended-Release Tablets 2.5/1000 mg (Linagliptin, Metformin)

Adult dose

This medication should be taken once daily with food, during the evening meal. To maintain its extended-release characteristics, it should be swallowed whole without breaking, crushing, grinding, or chewing. The 5/1000 mg extended-release tablet should be taken once daily, one tablet at a time. The 2.5/1000 mg extended-release tablet should be taken once daily, two tablets at a time. The initial dosage is Linagliptin 5 mg and Metformin Hydrochloride 1000 mg, with the Metformin Hydrochloride taken at a daily dose.

This medication can rarely cause serious lactic acidosis or hypoglycemia, so caution is required. Patients with allergies to the components of this medication, or those with type 1 diabetes, lactic acidosis, or diabetic ketoacidosis should not use this medication. Administration should also be avoided in patients with severely impaired kidney function or conditions that could affect kidney function such as acute infections, shock, severe trauma, etc. Patients with liver function disorders, gastrointestinal disorders, acute alcohol intoxication, or alcoholism should also refrain from using this medication. Pregnant women or women with a risk of placental dysfunction or preeclampsia should not use this medication. This medication carries a risk of hypoglycemia, so careful dose adjustment and blood sugar monitoring are required when used with insulin or sulfonylureas and other hypoglycemic agents. Due to the risk of lactic acidosis, special caution is needed in cases with risk factors such as dehydration, cardiovascular disease, liver disease, and excessive alcohol consumption. Kidney function should be regularly tested, and if abnormalities are found, consultation with healthcare professionals should be sought immediately. If symptoms of acute pancreatitis or bullous pemphigoid appear, discontinue the medication immediately and consult a physician. This medication should be swallowed whole without crushing, breaking, or chewing, and the tablet shell may pass in your stool, which is normal. This medication may interact with other drugs, so inform your healthcare provider about all medications you are taking. Elderly patients are more likely to have impaired kidney function, so dose adjustments and regular kidney function tests are necessary. Pregnant or breastfeeding women should avoid using this medication, and if pregnancy is planned, consultation with healthcare providers is advised. In cases of overdose, the drug may not be completely absorbed from the gastrointestinal tract, but due to the risk of lactic acidosis, immediate hospital treatment is required. This medication should be stored out of reach of children and protected from moisture.

Serious side effects

Hives, severe swelling (including angioedema), angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, liver function abnormalities (including liver function impairment, hepatitis, etc.), angina, acute myocardial infarction, unstable angina, cardiac arrest, heart failure, acute kidney injury, end-stage renal disease, severe edema accompanied by increased blood pressure, chest tightness, difficulty breathing, asthma attacks, severe allergic reactions, severe skin adverse reactions, respiratory issues, jaundice, severe nervous system complications.

Mild side effects

Nasopharyngitis, hypersensitivity reactions, hypoglycemia (when used in combination), taste disturbances, cough, loss of appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, liver function abnormalities, hepatitis, itching, erythema, rashes, non-severe joint pain, increases in lipase enzymes, increase in amylase, abnormal vitamin B12 absorption tests, angioedema, increased triglycerides in the blood, decreased hemoglobin levels, increased potassium levels in the blood, increased creatinine levels in the blood.

This medication can be sensitive to air or moisture, so it should be stored in a tightly sealed container. Additionally, it is best stored at room temperature, between 1 to 30 degrees Celsius, ensuring it is not too hot or too cold.

Appearance

Yellow, oval-shaped, biconvex, extended-release film-coated tablet

Package unit

30 tablets/bottle