Sitadual XR Extended-Release Tablet 50/500 mg (Sitagliptin Hydrate, Metformin Hydrochloride)

Adult dose

This medication should be taken once daily in the evening with meals to reduce gastrointestinal adverse reactions caused by metformin, with gradual dose increases. To maintain the extended-release characteristic, swallow whole without splitting, crushing, chewing, or dissolving. The 100/1000 mg extended-release tablet is taken once daily, with 1 tablet per dose. The 50/500 mg or 50/1000 mg extended-release tablet is taken once daily, with 2 tablets per dose.

This medication contains two ingredients for the treatment of diabetes. The first ingredient helps in regulating blood sugar, while the second ingredient is effective at lowering blood sugar. The most important point while taking this medication is to be cautious of allergic reactions. Rarely, severe allergic reactions or skin conditions may occur, so if symptoms such as skin rash, itching, or difficulty breathing arise, stop taking the medication immediately and consult a physician. Additionally, there is a risk of pancreatitis, which involves inflammation of the pancreas, so if symptoms such as abdominal pain, vomiting, or fever occur, inform medical personnel immediately. It is also recommended to avoid this medication in patients with poor kidney function, dehydration, serious infections, or heart disease for safety. Patients with reduced kidney function should consult a physician before taking this medication and undergo regular kidney function tests. Pregnant or nursing women should not take this medication, and safety and efficacy have not been established in children under 18 years of age. During treatment, be mindful that irregular meals, excessive exercise, or other medications may cause hypoglycemia. Particularly, when taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, so it is important to monitor blood sugar levels frequently. Alcohol consumption should be avoided while taking this medication, as acute alcohol intoxication or impaired liver function may cause severe side effects such as lactic acidosis. Stop taking this medication temporarily if undergoing surgery or tests that use contrast agents, and the decision to resume should be based on kidney function test results. This medication may decrease vitamin B12 levels, so if taking it long-term, it is advisable to check vitamin B12 status regularly through blood tests. Finally, in the case of an overdose, immediately seek medical attention for appropriate treatment, as some ingredients can be removed by dialysis. As this medication has various precautions and side effects, it is essential to consult with a physician or pharmacist before taking it and follow their instructions.

Serious side effects

Hives, angioedema, anaphylaxis, exfoliative skin disease (including Stevens-Johnson syndrome), acute pancreatitis, acute renal failure, hypoglycemia (including severe), elevated liver enzymes, bullous pemphigoid, thrombocytopenia, rhabdomyolysis, lactic acidosis, severe and debilitating joint pain, severe allergic reactions, severe skin adverse reactions, liver abnormalities (jaundice), severe swelling or urinary abnormalities, respiratory issues, severe neurological symptoms

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nasopharyngitis
• nausea
• vomiting
• abdominal pain
• constipation
• joint pain
• muscle pain

Store this medication in a sealed container as it is sensitive to air and moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius. This will help preserve the medication's effectiveness and safety over time.

Appearance

Light blue, oval-shaped, bi-convex extended-release film-coated tablets

Package unit

Bottle - 100 tablets/bottle, bottle - 30 tablets/bottle