Sinubim XR Coated Tablets 50/500 mg (Sitagliptin, Metformin)

Adult dose

This medication is taken once daily with dinner to reduce gastrointestinal adverse reactions caused by metformin, with gradual dose escalation. To maintain the extended-release properties, do not split, crush, chew, or break tablets; swallow whole. The 100/1000 mg extended-release tablet is taken once daily, with one tablet per dose. The 50/500 mg or 50/1000 mg extended-release tablets are taken once daily, with two tablets per dose.

This medication is a diabetes treatment that contains two ingredients: sitagliptin and metformin. First, sitagliptin can rarely cause serious allergic reactions. Symptoms such as anaphylaxis, angioedema, or severe skin disorders may occur, so if these symptoms appear, discontinue use immediately and consult a doctor. Additionally, sitagliptin may induce acute pancreatitis, which is inflammation of the pancreas, and if symptoms such as abdominal pain, vomiting, or severe discomfort in the abdomen occur, seek medical attention immediately. Metformin can cause a rare complication known as lactic acidosis, a serious condition in which lactic acid builds up in the body, presenting symptoms like muscle pain, difficulty breathing, fatigue, and abdominal pain. If these symptoms occur, discontinue medication and consult a healthcare professional immediately. This medication should not be administered to patients with significantly impaired kidney function, acute heart failure, acute myocardial infarction, severe infections, dehydration, acute metabolic acidosis, or to women who are pregnant or breastfeeding. Patients scheduled for surgery should temporarily stop taking this medication 48 hours prior to surgery and resume only after confirming normal kidney function post-surgery. Care should be taken if taking other medications that can increase or decrease blood sugar levels, especially in combination with insulin or sulfonylureas, as the risk of hypoglycemia may increase. Gastrointestinal symptoms such as diarrhea, nausea, vomiting, and headaches may occur during treatment, and if these symptoms persist, consult a healthcare professional. Elderly patients may experience decreased kidney function, so regular kidney function tests and appropriate dose adjustments are important. As vitamin B12 levels may decrease, regular blood tests to monitor vitamin B12 status are advisable during long-term use. During treatment, excessive alcohol consumption should be avoided, as alcohol can increase the risk of lactic acidosis. Finally, this medication should not be used in pediatric patients under the age of 18, as safety and efficacy have not been established. If atypical symptoms occur while taking this medication, consult a doctor immediately and adhere to the prescribed dosage and administration.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, Stevens-Johnson syndrome, exfoliative skin disorders, severe allergic reactions, severe rash and blisters accompanied by high fever, desquamation, mucosal pain in the mouth/eyes, acute pancreatitis, acute renal failure, difficulty breathing, severe swelling, swelling accompanied by elevated blood pressure, jaundice (yellowing of the skin or eyes), liver abnormalities, sudden and severe headache, thunderclap headache, seizures.

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, hypoglycemia, elevated liver enzymes, increased white blood cell count, decreased vitamin B12 levels, severe joint pain accompanied by disability

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage will maintain the medication's efficacy and safety.

Appearance

Bright blue, oval-shaped, biconvex, extended-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle