Atovazine Plus Tablet 10/10 mg (Ezetimibe, Atorvastatin Calcium Trihydrate)

Adult dosage

This medication is administered once daily, regardless of meals. The dosage range for primary hypercholesterolemia is 10/10 mg to 10/80 mg per day. An initial dose of 10/10 mg or 10/20 mg per day is suggested. If more LDL cholesterol reduction is needed, an initial dose of 10/40 mg per day is advised. After starting the medication or adjusting the dose, monitor blood lipid levels at intervals of more than 2 weeks before adjusting the dosage.

This medication may cause a rare side effect called rhabdomyolysis, which can affect muscles. There is a risk of kidney problems due to this; therefore, the medication should be temporarily suspended or discontinued, especially in cases of acute infection, hypotension, or after major surgery where there are risk factors. This medication should not be administered to specific patients, such as those allergic to the drug's components, those with severely impaired liver function, patients with muscle disorders, pregnant or nursing women, individuals currently taking certain antiviral medications, and patients with lactose intolerance. In patients with liver or muscle issues, elderly patients, and those taking certain other medications, this drug should be used with caution. Particularly, patients with decreased liver function should have their liver enzyme levels frequently monitored. If symptoms such as muscle pain, muscle weakness, fatigue, or fever occur while taking this medication, the doctor should be notified immediately, and blood tests should be performed as needed to check for muscle damage. If muscle damage is significant, the medication may be discontinued. Women who are pregnant or may become pregnant should not take this medication, and women of childbearing age should use appropriate contraception while taking it. It is also advised that nursing women refrain from taking this medication. This medication is not recommended for children as safety and efficacy have not been established. Elderly individuals are at a higher risk of muscle-related issues, so caution is necessary, although dosage adjustments are generally not required. In case of overdose, there are no specific antidotes, and treatment should focus on symptom management, alongside testing for liver function and muscle damage. This medication may interact with various drugs; therefore, individuals taking other medications should inform their doctor or pharmacist. Caution is particularly important when taken with drugs that inhibit or induce enzymes that metabolize medications in the liver. Lastly, regular monitoring of liver function and muscle status is essential while taking this medication, and any unusual symptoms should be reported to healthcare providers immediately.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with coughing and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination.

Mild side effects

• Muscle pain
• abdominal pain
• increased liver enzymes
• dizziness
• cough
• nausea
• diarrhea
• joint pain
• muscle weakness
• musculoskeletal pain

This medication should be stored in a tightly sealed container to protect it from air and moisture, ideally at a temperature between 1 and 30 degrees Celsius. Therefore, avoid storing it in excessively hot or cold locations.

Appearance

White or off-white oblong film-coated tablet

Package unit

30 tablets/box [(10 tablets/Alu-Alu × 3)]