Sitagliptin 25 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dosage

The usual dosage is 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken with or without food. In cases of renal impairment, dosage adjustments are necessary according to renal function. - In moderate renal impairment (glomerular filtration rate 30-45 mL/min/1.73 m2), the dosage is 50 mg once daily. - In severe renal impairment (glomerular filtration rate 15-30 mL/min/1.73 m2), the dosage is 25 mg once daily.

This medication may cause allergic reactions, so if symptoms such as skin rash or difficulty breathing occur, discontinue use immediately and consult a physician. During the use of this medication, if symptoms of pancreatitis such as abdominal pain, nausea, or vomiting occur, inform medical personnel immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Patients with impaired renal function need dosage adjustments, so regular kidney function tests are required. When taken with other hypoglycemic agents, especially insulin or sulfonylureas, the risk of hypoglycemia may increase, so blood glucose levels should be monitored closely. If severe joint pain or skin blisters appear during treatment with this medication, inform a physician immediately, and discontinue use if necessary. Pregnant or lactating women should not take this medication, and safety in children under 18 has not been established. Elderly patients may have reduced renal function, necessitating dosage adjustments and kidney function testing. In cases of overdose, seek proper treatment at a medical facility immediately, as this medication can be partially removed by hemodialysis. This medication has minimal interactions with other drugs, but it is important to inform medical personnel when taking certain medications.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe allergic reactions, Stevens-Johnson syndrome and exfoliative skin diseases, severe skin adverse reactions, acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing), worsening renal function (including acute renal failure), severe and disabling arthralgia, bullous pemphigoid, severe hypoglycemia, liver abnormalities (elevated liver enzymes), cardiac arrest, pneumonia, diabetic complications, metabolic acidosis, fall

Mild side effects

• Rhinitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

Store this medication in a tightly sealed container to prevent air or moisture infiltration. It should be kept at room temperature between 1 to 30 degrees Celsius, away from extreme heat or cold.

Appearance

Pink, round, biconvex film-coated tablets

Package unit

28 tablets/box [14 tablets/PTP x 2]