Mega Hyaluron Injection (Sodium Hyaluronate)

Adult dosage

As sodium hyaluronate, administer 25 mg once a week for 5 consecutive weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or biceps tendon sheath). Adjust the number of administrations as appropriate according to symptoms. This medication is administered into the knee joint, so it should be performed under strict aseptic conditions.

This medication should not be administered to certain patients. For example, individuals who are allergic to this medication or its components, those with skin diseases or infections in the joint area, those with liver function issues or a history of liver disorders, and individuals allergic to avian proteins should not use it. Rarely, shock or allergic reactions may occur with this medication, so patients must be closely monitored after administration. If symptoms such as swelling around the face or eyes, rash, or itching occur, use should be discontinued immediately, and appropriate treatment should be initiated. There may be temporary pain, swelling, redness, warmth, or severe pressure at the injection site, as well as symptoms such as nausea, vomiting, fever, and headache. This medication may worsen inflammation in severely inflamed joints, so it is advisable to treat inflammation first before using this medication. Additionally, after injection, stabilization of the joint area should be maintained, and care should be taken to prevent leakage of the medication outside the joint. Patients with inflammatory arthritis such as rheumatoid arthritis or gouty arthritis may experience temporary exacerbation of inflammation. During the 48 hours following injection, intense exercise such as jogging or tennis, or exercises that involve prolonged weight-bearing should be avoided. It is advisable not to use this medication in conjunction with other intra-articular injectables as safety and effectiveness have not been verified. Women who are pregnant or may become pregnant should use this medication with caution, and it is safest to avoid use while breastfeeding. Safety has not been established for children, so it should only be used with caution in necessary cases. Elderly patients may have decreased bodily functions, so caution is necessary when using this medication. This medication must be precisely injected intra-articularly in a sterile environment, and administration should be discontinued if symptoms do not improve within 5 doses. If there is excess joint fluid, it is advisable to remove it prior to injection. Intravascular injection is strictly prohibited, and this medication should not be used for ophthalmic purposes. During injection, an appropriate needle should be used, and the ampoule should be shaken to ensure even content before slowly injecting it into the syringe. When cutting the ampoule, it is safest to clean it thoroughly to prevent contaminants from entering. Caution should be exercised as mixing with certain disinfectants may produce precipitates, and any opened single-use ampoule should be used quickly, with any remaining portion disposed of. Administering a local anesthetic prior to this injection can help alleviate pain.

Serious side effects

Urticaria, swelling (such as facial or eyelid swelling), shock

Mild side effects

• Facial flushing
• itching
• pain
• swelling
• redness
• warmth
• severe pressure at the injection site
• petechial hemorrhage
• nausea
• vomiting

This medication should be stored in a sealed container to prevent exposure to air and moisture, at a temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication.

Appearance

A colorless, transparent viscous solution filled in a glass vial sealed with rubber stoppers at both ends (part of a prefilled syringe system)

Package unit

2.5 milliliters × 10, 50, 100 vials