Agril Tablet 2 mg (Glymeperide)

Adult dose

Adjusted individually for each patient. Take without chewing, with more than 1/2 cup of water. Administer once daily orally. It should be taken before breakfast or immediately before the first meal, and it is crucial not to miss a meal after administration. For monotherapy, the initial dose is 1 mg of glymeperide once daily, and if needed, increase by 1 mg at intervals of 1-2 weeks. Generally, it is administered at doses above 4 mg.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or those in a coma. It is also prudent to avoid administering this medication to patients with an allergy to this drug or its components, severe liver or kidney dysfunction, or in pregnant or breastfeeding women. In patients with severe infections, major surgeries, or severe trauma, conversion to insulin therapy is recommended. Care is necessary as gastrointestinal issues can affect drug absorption leading to a risk of hypoglycemia. Patients with lactose intolerance or certain genetic metabolic disorders should not take this medication. During the first week of administration, the risk of hypoglycemia is high, so blood sugar status must be closely monitored, particularly in older adults, those with poor nutritional status, irregular meal patterns, those with impaired kidney or liver function, and those taking other medications. If hypoglycemic symptoms occur, sugar should be consumed immediately, and it is advisable to always carry sugar for this purpose. In case of severe hypoglycemia, immediate medical attention may be required, so one should go to the hospital promptly if symptoms occur. This medication must be used in conjunction with dietary and exercise therapy for blood sugar control and consistent intake is essential. There may be interactions with other medications, so it is crucial to inform healthcare providers about any other medications being taken. It is safest for pregnant or breastfeeding women not to use this medication and to consider switching to insulin therapy if necessary. Safety and efficacy have not been established in children under 18 years of age, so it should not be used in this population. In older adults, attention should be paid to dosage adjustment due to the common decline in renal function. In cases of overdose, severe hypoglycemia may occur, necessitating immediate first aid and professional treatment at a hospital. This medication should be stored out of reach of children and kept in its original container.

Serious side effects

• Hives, severe swelling (edema), difficulty breathing, shock, and other severe allergic reactions
• Serious hypersensitivity reactions such as angioedema, mucocutaneous syndrome (Stevens-Johnson syndrome)
• Liver dysfunction (including jaundice), liver failure
• Severe thrombocytopenia accompanied by a platelet count below 10,000/μL and thrombocytopenic purpura
• Stroke-like symptoms due to severe hypoglycemia (serious neurological symptoms)

Mild side effects

• Symptoms of hypoglycemia: headache, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, decreased initiative, depression, confusion, speech disturbances, visual disturbances, tremors, partial paralysis, sensory disturbances, dizziness, weakness, loss of self-control, mental confusion, seizures, drowsiness, loss of consciousness, coma, shallow breathing, bradycardia
• Adrenaline counterregulatory symptoms: sweating, cold clammy skin, anxiety, tachycardia, hypertension, palpitations

This medication should be kept in a sealed container to prevent exposure to air or moisture, and it is suggested to store at room temperature between 1 to 30 degrees Celsius. Therefore, it is important to avoid direct sunlight and not to place the medication in excessively hot or cold locations to maintain its efficacy.

Appearance

Green rectangular tablet

Package unit

30 tablets/bottle, 100 tablets/bottle