Pioglm Tablet

Adult dosage

The dosage of this medication should be individualized based on the efficacy and tolerability, not exceeding pioglitazone 30mg and metformin 2500mg. The initial dosage is based on the patient’s current treatment regimen, with monotherapy patients starting with 1 tablet daily, gradually adjusting the dosage based on therapeutic response. Patients transitioning from combination therapy may start with their existing doses. This medication is generally taken with meals.

This medication can cause a rare side effect known as severe lactic acidosis, therefore, patients with impaired kidney function or liver dysfunction should avoid using it. Lactic acidosis can manifest as symptoms such as muscle pain, weakness, and difficulty breathing, and if these symptoms occur, the doctor should be notified immediately. This medication may pose a risk of worsening edema or heart failure in patients with heart failure, so those with heart disease should use it cautiously. Patients with active bladder cancer or a history of bladder cancer should not use this medication, and if bladder-related symptoms occur, immediate medical consultation is required. Women who are pregnant or breastfeeding should not take this medication, and its safety and efficacy have not been confirmed in children. Elderly patients may have reduced kidney function, so dosing should be carefully adjusted, and regular kidney function tests should be performed. There may be interactions with other medications, so if other medications are currently being taken, the doctor or pharmacist must be informed. In case of overdose, immediate medical attention must be sought, and particularly in cases of reduced kidney function, dialysis may be necessary. While taking this medication, excessive alcohol consumption should be avoided, and regular meals, exercise, and routine blood sugar and kidney function tests should be strictly followed.

Serious side effects

Severe lactic acidosis, hypoglycemia, death due to lactic acidosis, acute kidney injury, cardiopulmonary disease, sepsis, hypoxia, resistant bradyarrhythmias, decreased blood pH, increased blood lactate levels, liver abnormalities (jaundice), fatal and non-fatal liver failure, heart failure (including congestive heart failure), excessive edema, fluid retention, heart failure symptoms (including difficulty breathing and edema), severe heart failure (Class 3 and 4 by the New York Heart Association), hematuria, urination disorders

Mild side effects

• Upper respiratory tract infection
• diarrhea
• nausea
• headache
• urinary tract infection
• sinusitis
• dizziness
• lower limb edema
• weight gain
• muscle pain

This medication should be stored in a tightly closed container to avoid exposure to air and moisture. It is advisable to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

White to grayish-white oblong film-coated tablet

Package unit

30 tablets (10 tablets/PTP*3)