Prien EF Soft Capsule (Naproxen)

Adult dose

1. Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: Administer 250–500 mg of naproxen orally twice a day (every 12 hours). 2. Acute gout: Administer an initial dose of 750 mg orally and continue with 250 mg orally every 8 hours until the attack resolves. 3. Skeletal muscle disorders, post-surgical pain, post-extraction pain, dysmenorrhea, tendinitis, bursitis: Administer an initial dose of 500 mg orally.

This medication may increase the risk of gastric bleeding in individuals who regularly consume more than three alcoholic beverages a day, so consultation with a doctor or pharmacist is necessary. This medication may increase the risk of cardiovascular disease and could lead to serious issues like myocardial infarction or stroke, so individuals with cardiovascular diseases or risk factors should exercise special caution. This medication can cause serious adverse reactions such as bleeding, ulcers, or perforations in the stomach or intestines, which may be particularly dangerous for the elderly. Individuals with a history of peptic ulcers or severe liver, kidney, or heart dysfunction, and those allergic to this medication or similar medications should not take it. Individuals with hypersensitivity or a history of allergic reactions such as asthma, rhinitis, or urticaria should also avoid this medication. During the use of this medication, if symptoms of gastric bleeding, cardiovascular symptoms, skin rashes, or respiratory distress occur, the use should be immediately discontinued and a doctor consulted. This medication may increase the risk of adverse effects when taken with other non-steroidal anti-inflammatory drugs or certain medications, so it is essential to inform the healthcare provider of any other medications being taken. During pregnancy, especially in late pregnancy, it may pose a risk to the fetus, so use should be avoided. It is also advisable for breastfeeding individuals to refrain from taking this medication as it may pass into breast milk and affect the baby. It is advisable to avoid this medication in young children, particularly infants under the age of two, due to uncertain safety. Elderly patients are at higher risk of adverse effects like gastric bleeding, so they should start at the lowest dose and be monitored closely. For long-term use of this medication, regular blood tests and liver and kidney function tests should be conducted to check for abnormalities. In case of overdose, symptoms such as drowsiness, indigestion, nausea, and vomiting may occur, requiring immediate emergency treatment. This medication should be stored out of reach of children and care should be taken not to transfer it to other containers.

Serious side effects

• Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat → severe allergic reaction
• Hematemesis, gastrointestinal bleeding, peptic ulcer, perforation → serious gastrointestinal adverse reactions
• Fever, wheezing, coughing → pulmonary infiltrate (PIE syndrome)
• Agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia, hemolytic anemia, platelet dysfunction → blood disorders
• Jaundice, hepatitis → liver abnormalities
• Kidney disorders, glomerulonephritis, hematuria, interstitial nephritis,

Mild side effects

• Nausea
• abdominal pain
• vomiting
• loss of appetite
• dyspepsia
• heartburn
• diarrhea
• constipation
• stomatitis
• abdominal bloating

Drug interactions

Do not take this medication with other non-steroidal anti-inflammatory drugs and naproxen derivatives. Phenytoin-based antiepileptic drugs, sulfa drugs, sulfonylurea blood glucose-lowering agents, propranolol and other beta-blockers, ACE inhibitors (such as captopril), loop and thiazide diuretics, probenecid, aspirin, lithium, methotrexate, coumarin-based anticoagulants (such as warfarin), zidovudine, fluoroquinolone antibiotics (such as enoxacin)

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it should be kept in a cool room, maintaining a temperature between 1 degree and 30 degrees Celsius.

Appearance

Yellow transparent oval soft capsules containing a colorless to pale yellow transparent content

Package unit

10 capsules/PTP