Levoef 500 mg Tablet (Levofloxacin Hydrate)

Adult dose

Typically, for adults, Levofloxacin is administered orally at a dose of 250-750 mg once daily. For patients with normal renal function, the dosage and duration for each indication are as follows: - Complicated skin and soft tissue infections: 750 mg every 24 hours for 10-14 days - Community-acquired pneumonia: 500 mg every 24 hours for 7 days - Acute bacterial exacerbation of chronic bronchitis: 7 days - Acute sinusitis: 10-14 days - Chronic bacterial prostatitis: 28 days - Complicated urinary tract infections including mild to moderate acute pyelonephritis: 250 mg every 24 hours for 10 days - Uncomplicated urinary tract infections: 3 days

This drug is a fluoroquinolone antibiotic used for the treatment of various bacterial infections. However, this medication can cause serious side effects such as tendonitis or tendon rupture, peripheral neuropathy, central nervous system disturbances, and worsening of myasthenia gravis. If these symptoms occur, the medication should be stopped immediately, and similar class medications should not be used. Patients with myasthenia gravis may experience worsening symptoms if this drug is taken, so it is not administered to them. Additionally, it is used only when there are no other treatment options for specific infections such as acute bacterial rhinosinusitis, acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease, uncomplicated urinary infections, and acute otitis media. Elderly patients, patients with impaired kidney function, transplant recipients, those receiving high doses or taking corticosteroids are at increased risk of tendon rupture and should be cautious. Particularly, concomitant use with corticosteroids should be avoided, and if pain, inflammation, or tendon rupture symptoms occur, medication should be stopped immediately. This drug has neuromuscular blocking effects and may cause serious side effects in patients with myasthenia gravis, so it should be used with caution. Patients who previously had allergic reactions to this drug or similar medications, those with a history of tendonitis or tendon rupture, adolescents under 18 in their growth phase, pregnant or breastfeeding women, epilepsy patients, or those with certain genetic diseases should not receive this medication. Patients with severe kidney dysfunction, central nervous system diseases, a history of seizures, those taking certain anti-inflammatory drugs or theophylline, elderly people, diabetic patients, glucose-6-phosphate dehydrogenase deficiency patients, and those with a history of aortic aneurysm or valvular heart disease should be given this medication with caution. This drug may cause various side effects including severe allergic reactions, neuropsychiatric symptoms, cardiac arrhythmias, renal and hepatic dysfunction, hematological abnormalities, gastrointestinal issues, musculoskeletal problems, skin diseases, and respiratory issues. Particularly, if severe reactions occur on the skin, the medication should be stopped immediately and medical advice should be sought. This drug may increase the risk of seizures, so caution is needed for patients with epilepsy or central nervous system diseases. During treatment, avoid strong sunlight or artificial ultraviolet exposure, and be cautious of symptoms such as dizziness or drowsiness when driving or operating machinery. This drug may have reduced absorption when taken with certain antacids, iron, calcium, zinc, multivitamins, etc., so dosing intervals should be adjusted. Also, be aware that interactions with certain drugs may increase blood concentration variations or the risk of side effects, so be sure to inform your healthcare provider of any medications being taken. Women who are pregnant or breastfeeding should not take this drug, nor should it be administered to children and adolescents in the growth phase. Elderly patients may experience increased drug concentrations due to decreased kidney function and should adjust the dosage and dosing intervals while being mindful of hepatotoxic side effects. In case of overdose, central nervous system symptoms and heart issues may occur, requiring immediate treatment; this drug cannot be removed via hemodialysis. If any adverse reactions occur while taking this medication, immediate consultation with medical personnel for appropriate measures should be undertaken.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attacks, cough with fever and respiratory abnormalities, yellowing of the skin or eyes (jaundice), extreme malaise, sudden and very severe headache, lightning headaches, seizures, confusion, vision abnormalities, paralysis, urination

Mild side effects

• Nausea
• diarrhea
• vaginitis
• insomnia
• abdominal pain
• bloating
• itching
• dizziness
• rash
• indigestion

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. Additionally, it is advisable to store it at room temperature between 1 degree and 30 degrees Celsius.

Appearance

Pink, rectangular, film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle