Hanubi Tablet 100 mg (Sitagliptin Phosphate)

Adult dose

This medication is administered once daily at a dose of 100 mg for either monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with renal impairment, adjustments in dosage may be necessary according to renal function. - Mild renal impairment (eGFR 60 or above but less than 90): No dosage adjustment needed - Moderate renal impairment (eGFR 45 or above but less than 60): No dosage adjustment needed - Moderate renal impairment (eGFR 30 or above but less than 45): Administer 50 mg once daily. - Severe renal impairment (eGFR 15 or above but less than 30) or end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis (eGFR less than 15): Administer 25 mg once daily; this medication can be taken irrespective of dialysis timings.

This medication can rarely cause severe allergic reactions, so if skin rash, difficulty breathing, or swelling of the face or neck occurs after taking it, you should immediately stop taking it and consult a doctor. During administration, symptoms of acute pancreatitis such as severe abdominal pain, vomiting, and fever may occur; if these symptoms appear, immediate medical attention should be sought. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and it should be avoided in case of allergy to this medication or its components. Patients with reduced kidney function should have their dosage adjusted, and regular kidney function tests are important. Hypoglycemic symptoms may occur during treatment, and the risk of hypoglycemia may increase, especially when taken together with other hypoglycemic agents such as insulin or sulfonylureas. If severe joint pain or skin blisters occur, you should notify your doctor immediately and discontinue the medication. Pregnant and nursing women are not recommended to use this medication, and safety for children and adolescents under 18 years old has not been established. Elderly patients may require dosage adjustment and kidney function testing due to potential renal impairment. In cases of overdose, general treatment procedures may be considered, and dialysis may be required based on necessity; therefore, dosage must be strictly adhered to. This medication has little to no significant interactions with various other medications, but it is advisable to consult healthcare professionals when taking certain medications. It is important to consult healthcare professionals immediately if any abnormal symptoms or discomfort arise during administration.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, severe allergic reaction, serious skin reactions (Stevens-Johnson syndrome, exfoliative skin disease, pemphigoid-like blistering), acute pancreatitis (hemorrhagic or necrotizing, fatal or non-fatal), difficulty breathing, respiratory problems, liver abnormalities (jaundice of the skin or eyes, elevated liver enzymes), severe neurological symptoms (seizures, confusion, etc.), severe swelling or urination abnormalities (acute

Mild side effects

• Hypoglycemia
• upper respiratory tract infections
• nasopharyngitis
• constipation
• vomiting
• headache
• joint pain
• muscle pain
• limb pain
• back pain

Store this medication in a tightly closed container to prevent air exposure, and it is advisable to keep it at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's efficacy and prevent deterioration.

Appearance

Beige, round, biconvex film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]