Cephalon Capsule 250 mg (Cefaclor Hydrate)

Adult dose

For cefaclor hydrate, the oral dosage is 250 mg (potency) every 8 hours. In cases of severe infections (such as pneumonia) and infections with low susceptibility, the dose may be doubled. For acute gonococcal urethritis, administer 3 g of this drug combined with 1 g of probenecid in a single dose.

Child dose

Administer 20 mg (potency) per kg of body weight divided every 8 hours. In cases of severe infections, otitis media or infections with low susceptibility, a dosage of 40 mg (potency) per kg of body weight may be administered daily, with a maximum dosage of

This drug is an antibiotic that kills bacteria by binding to specific proteins and inhibiting the synthesis of their cell walls. Before using this drug, patients who have previously experienced severe allergic reactions or shock from this drug or similar antibiotics should never take it. Furthermore, patients with allergies to penicillin antibiotics or those prone to allergy symptoms such as asthma or skin rashes should use this drug cautiously. Patients with severely impaired kidney function, older adults, or patients with poor nutritional status or difficulty with oral intake should be particularly monitored as vitamin K deficiency symptoms may occur. Patients with a history of gastrointestinal diseases, especially colitis, should also exercise caution when using this drug. This drug may rarely cause severe allergic reactions such as shock or anaphylaxis, so symptoms should be closely observed during administration, and if symptoms arise, drug use should be immediately discontinued and appropriate treatment sought. Serious skin diseases, such as Stevens-Johnson syndrome, may also rarely occur, so any abnormal skin symptoms should be reported to a healthcare provider promptly. Regular blood tests are necessary as there may be anomalies such as leukopenia, anemia, or thrombocytopenia; if abnormalities are detected, drug use may need to be terminated. As this drug may also affect liver and kidney function, any signs of hepatitis or suspected kidney function decline should be immediately brought to the attention of a healthcare provider. Gastrointestinal symptoms may include abdominal pain, diarrhea, and vomiting; if there is any blood in stools or severe diarrhea, drug use should be immediately stopped. Respiratory symptoms may rarely include pneumonia; if there are respiratory difficulties or cough, it should be reported immediately. CNS symptoms may include anxiety, restlessness, dizziness, and drowsiness, although these are rare. This drug can cause dysbiosis, such as stomatitis or candidiasis, so oral hygiene should be maintained. There may also be rare occurrences of bleeding tendencies or vitamin B deficiencies due to vitamin K deficiency, so patients should be vigilant for symptoms of bleeding or neurological abnormalities. Drug interactions may occur, so especially in cases where anticoagulants, diuretics, or oral contraceptives are taken, consultation with a healthcare provider is essential. Women who are pregnant or breastfeeding should consider the risks and benefits adequately before taking this drug, as its safety has not been fully established. Use in newborns less than one month old should be avoided as safety and efficacy have not been confirmed. Older adults may experience adverse reactions more easily due to declining physiological function, so dosage and administration intervals should be adjusted and used cautiously. During the use of this drug, regular clinical tests are recommended, and precaution should be taken in interpreting test results as false positives may occur in urine glucose tests or direct Coombs tests.

Serious side effects

Shock, anaphylactic symptoms (generalized flushing, swelling, difficulty breathing, angioedema, sensory disturbances, fainting, hypertension, vasodilation), urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, granulocytopenia, pancytopenia, anemia, thrombocytopenia, aplastic anemia, hemolytic anemia, reversible neutropenia, transient hepatitis, jaundice, elevated AST, ALT, ALP, reversible interstitial nephritis, elevated BUN.

Mild side effects

• Rash
• itching
• fever
• lymphadenopathy
• arthralgia
• serum sickness-like reactions
• nausea
• vomiting
• diarrhea
• abdominal pain

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. The recommended storage temperature is room temperature between 1 to 30 degrees Celsius. Proper storage will help safely maintain the medication's efficacy.

Appearance

A hard capsule with a purple upper part and a white lower part containing a yellowish powder.

Package unit

30 capsules/bottle, 300 capsules/bottle