Diroproprizine 5/160 mg (Amlodipine Besylate, Valsartan)

Adult dose

The recommended dosage is once daily, 1 tablet, taken with water regardless of meals. It is recommended to take it at the same time every day (e.g., in the morning).

Child dose

The safety and efficacy of this medication in pediatric patients under 18 years of age have not been established, so its use is not recommended.

This drug can cause serious harm to the fetus and newborn if taken during the second and third trimesters of pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Patients with allergies to the active ingredients, women who are pregnant or breastfeeding, patients with severe kidney or liver dysfunction, and those with specific heart conditions should not take this medication. Patients with low sodium or fluid levels in the body may experience hypotension, so it is essential to check the condition before taking it, and if symptoms of hypotension occur during use, appropriate measures should be taken immediately. Patients with high potassium levels should be cautious when taking this medication along with potassium supplements or other medications that elevate potassium levels, and frequent monitoring of blood potassium levels is required. Patients with kidney problems, kidney transplant recipients, and those with a history of angioedema should also be careful when taking this medicine, and if symptoms of angioedema arise, they should stop taking it immediately. Patients after heart failure or myocardial infarction should carefully monitor their kidney function and blood pressure when taking this medication, as there is a risk of pulmonary edema, and should follow medical instructions. This medicine may cause dizziness or fatigue when driving or operating machinery, so caution is necessary. When taken with other medications, interactions may occur, especially when combined with potassium-sparing diuretics, NSAIDs, certain antibiotics, simvastatin, CYP3A4 inhibitors or inducers. It is advisable to consult a doctor or pharmacist before combining. Women who are pregnant or planning to become pregnant should avoid taking this medication, and breastfeeding women are also advised to refrain from use. It is not recommended for children, as safety and efficacy have not been sufficiently established.

Serious side effects

Hives, severe swelling (angioedema), angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in the oral/ocular mucosa, shortness of breath or difficulty in breathing, asthma attacks, respiratory distress accompanied by cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances,

Mild side effects

• Headache
• dizziness
• drowsiness
• sensory disturbances
• lightheadedness
• tinnitus
• tachycardia
• palpitations
• syncope
• orthostatic hypotension

This drug should be stored in a tightly closed container to prevent air or moisture from entering and at room temperature between 1 to 30 degrees Celsius. Proper storage can help maintain the effectiveness of the medication.

Appearance

Dark yellow oblong film-coated tablet

Package unit

28 tablets (14 tablets/Alu-Alu packaging × 2)