Gumentin Tablet 625 mg (Amoxicillin Trihydrate · Clavulanate Potassium)

Adult dose

In adults and in children aged 12 years or older or weighing 40 kg or more, the dosage is 250 mg/125 mg of amoxicillin/clavulanate potassium administered orally three times a day every 8 hours. For severe and respiratory infections, the dosage may be increased to 500 mg/125 mg. In cases of renal impairment, adjust the dosage according to creatinine clearance. - CrCl ≥ 30 mL/min: No dosage adjustment needed. -

Child dose

In adults and children aged 12 years or older, or weighing 40 kg or more, administer 250 mg/125 mg of amoxicillin/clavulanate potassium orally three times a day every 8 hours. For severe and respiratory infections, the dosage may be increased to 500 mg/125 mg.

This medication is a beta-lactam antibiotic and should not be administered to certain patients. First of all, it should not be used in patients who have had allergic reactions to this medication or to other beta-lactam antibiotics. Caution is required for patients with viral infections such as infectious mononucleosis or lymphocytic leukemia due to the risk of rash. Moreover, patients with a history of liver dysfunction or jaundice related to this medication or to penicillin family drugs should avoid use due to the risk of recurrence. Patients with poor liver function or severe kidney dysfunction may have elevated drug concentrations, hence dosing intervals should be adjusted or used with caution. Patients with allergic constitution or those who frequently experience symptoms such as bronchial asthma or hives should be cautious as well. Patients who have difficulty with oral intake, elderly patients, or those in poor general condition may show symptoms of vitamin K deficiency, necessitating caution. Patients with gastrointestinal diseases suffering from severe vomiting or diarrhea may experience inadequate drug absorption. This medication can cause various gastrointestinal side effects, including diarrhea, vomiting, and abdominal pain, and in rare cases, gastrointestinal inflammation or severe colitis may occur. Symptoms of liver dysfunction may also occur, particularly in the elderly or males where it is reported more frequently. Skin itching or rash may develop, and in severe cases, serious skin reactions such as Stevens-Johnson syndrome may occur, requiring immediate discontinuation of the drug if such symptoms arise. Laboratory tests may occasionally reveal leukopenia, anemia, or thrombocytopenia, thus necessitating examination if any abnormal symptoms are present. The central nervous system can also be affected, leading to anxiety, drowsiness, headaches, and in severe cases, seizures, requiring particular caution in patients with poor kidney function. Acute kidney damage may occur, thus regular testing is necessary, and should there be any abnormal symptoms, the medication must be discontinued, and appropriate medical treatment should be sought. This medication can interact with other drugs, particularly necessitating caution when taken in conjunction with anticoagulants, certain antibiotics, or anti-inflammatory drugs. Women who are pregnant or breastfeeding should carefully consider the risks and benefits before using this medication, particularly avoiding it during the first three months of pregnancy. During breastfeeding, side effects such as diarrhea or skin rashes may occur in the infant, necessitating discontinuation if any abnormal signs arise. It is not recommended for children under 12 years or weighing less than 40 kg. Elderly patients may experience side effects more easily due to diminished body function, requiring adjustment of dosage and administration intervals and close monitoring of their condition. It is crucial to regularly check liver function, kidney function, and blood tests during the course of using this medication. In cases of overdose, symptoms like vomiting, diarrhea, drowsiness, rash, or in severe cases, seizures or renal failure may occur, and immediate medical attention is required.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, rash accompanied by high fever, blisters, peeling of skin, oral/ocular mucosal pain, severe skin abnormal reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough and fever, respiratory issues, yellowing of skin or eyes (jaundice), profound lethargy, liver abnormalities (jaundice), sudden and

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, abdominal bloating, constipation, colonic pain, gastric acidity, loose stools, dry mouth, candidiasis, antibiotic-associated colitis, elevated AST, ALT, ALP, LDH, serum bilirubin, hepatitis, itching, erythema multiforme, drug reaction (DRESS), angioedema, serum sickness-like syndrome, hypersensitivity vasculitis, acute generalized exanthematous pustulosis,

This medication is sealed in a special container to prevent humidity from entering. Additionally, it should be stored in a cool place between 1 and 25 degrees Celsius for safe keeping.

Appearance

White or almost white oval film-coated tablet

Package unit

4 tablets/PTP X 10