Piozole Tablet (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once daily regardless of meals. Initially, 15 mg once daily as monotherapy is recommended, and it may be increased to 30 mg once daily as needed. For combination therapy, 15 mg once daily is also administered. The maximum recommended dose is 30 mg once daily.

Child dose

Use in children under 18 years of age is not recommended as there is no experience with this population.

This medication aids blood sugar control in Type 2 diabetes patients and works by improving insulin resistance. When taking this medication, there is a risk of heart failure occurring or worsening in patients with compromised heart function, so symptoms such as changes in weight, shortness of breath, and swelling should be carefully monitored after treatment initiation. Patients with heart failure or a history of heart failure should not take this medication, and careful administration is necessary for patients with existing heart disease or a high risk of heart failure. This medication can cause fluid retention, leading to swelling, which may exacerbate heart failure symptoms, so immediate consultation with medical personnel is advised if symptoms occur. Additionally, patients with a history of bladder cancer or current active bladder cancer should not take this medication. If symptoms such as urinary disturbances or hematuria occur, inform a physician immediately. Patients with poor liver function or severe kidney impairment should also use this medication with caution, and liver enzyme levels should be monitored regularly. This medication carries a risk of hypoglycemia, so caution is necessary when taken with insulin or other hypoglycemic agents, and dosage adjustments of the concomitant medication may be required if hypoglycemic symptoms occur. In premenopausal women, this medication may promote ovulation, increasing the likelihood of pregnancy, so it is important to use appropriate contraceptive methods. Elderly patients or those in poor nutritional status, as well as those engaging in vigorous exercise, are also at risk of hypoglycemia and should use caution when taking this medication. During treatment, regular blood sugar and liver function tests should be conducted, and any abnormal symptoms should be reported to medical personnel immediately. Overdose may not produce specific symptoms, but tailored treatment may be necessary based on symptoms, so caution is needed. Finally, the safety and efficacy of this medication have not been established for children and it is not recommended for use in this age group.

Serious side effects

• Congestive heart failure
• worsening heart failure
• edema (including severe edema)
• shortness of breath
• respiratory distress
• heart failure
• stroke
• myocardial infarction
• urticaria
• severe allergic reactions

Mild side effects

• Upper respiratory tract infections
• headache
• sinusitis
• muscle pain
• pharyngitis
• abdominal bloating
• weight gain
• hypoglycemia
• urinary tract infection
• back pain

This medication should be stored in a tightly closed container that can prevent air and moisture exposure. It should be kept in a cool, dry place away from direct sunlight, ideally at room temperature between 1°C and 30°C.

Appearance

White to grayish-white, convex cylindrical tablet

Package unit

30 tablets/bottle, 100 tablets/bottle