Rotain Plus F Tablets

Adult dose

The usual dose of this drug is 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide once daily, in one tablet. Dosages exceeding 100 mg of losartan potassium and 25 mg of hydrochlorothiazide per day are undesirable. If blood pressure is not controlled, the dosage may be gradually increased. Patients with renal impairment should receive the usual dose if the creatinine clearance is more than 30 mL/min.

Child dose

There is no experience in using this medication in children and adolescents, so the losartan-hydrochlorothiazide combination should not be administered to them.

This drug can cause serious harm to the fetus if taken during pregnancy, especially in the second and third trimesters, so use should be discontinued immediately if pregnancy is confirmed. Those who are allergic to this medicine or its components, have severely impaired kidney function or anuria, have severe liver impairment, or specific electrolyte imbalances should not take this medication. Individuals with special health conditions such as hypotension, kidney disease, liver disease, diabetes, gout, or elderly patients should consult a physician before taking this medication, as it may lower blood pressure excessively. Due to the hydrochlorothiazide component, electrolyte imbalances can occur, necessitating regular blood tests and symptom monitoring, particularly for hypokalemia or hypercalcemia. This drug may interact with other medications; therefore, potassium supplements or medications containing potassium should not be taken arbitrarily and one must consult healthcare providers. Dizziness or drowsiness may occur during treatment, so caution is required when driving or operating machinery. This medication may increase sensitivity to sunlight, requiring sun protection and precautions when going outdoors, and any skin abnormalities should be reported to a doctor immediately. In breastfeeding, this drug may pass into mother’s milk and affect the baby, so breastfeeding should be stopped or discussed with a doctor. Safety has not been established for children and adolescents, so this drug should not be administered to them. In cases of overdose, symptoms such as hypotension or cardiac abnormalities may occur, requiring immediate medical attention; this drug is not removed by hemodialysis. Store this medication in its original container and keep it out of reach of children.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, mucosal pain in mouth/eyes, jaundice (yellowing of skin or eyes), severe lethargy, serious neurological symptoms (sudden and severe headache, lightning headache, seizures, mental confusion, visual disturbances, paralysis), markedly reduced urine output, severe swelling throughout the body, blood pressure changes.

Mild side effects

• Abdominal pain
• swelling
• palpitations
• back pain
• dizziness
• cough
• sinusitis
• upper respiratory infection
• weakness/fatigue
• diarrhea

This medicine should be stored in a container that blocks light and air, and it is recommended to store it at room temperature between 1 to 30 degrees Celsius. Storing it this way can help maintain the drug's effectiveness for a longer period.

Appearance

Pale yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle