Acepen Soft Capsule (Naproxen)

Adult dose

1. Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis Naproxen: 250～500 mg (1 capsule~2 capsules) orally administered twice a day (every 12 hours). 2. Acute gout Initial dosage: 750 mg (3 capsules) orally administered, then 250 mg (1 capsule) orally every 8 hours until the attack subsides. 3. Skeletal muscle disorders, post-surgical pain, pain after tooth extraction, dysmenorrhea, tendinitis, bursitis Initial dosage:

This medication should be consulted with a doctor or pharmacist if taken by individuals who regularly consume three or more alcoholic beverages per day, as it may increase the risk of gastrointestinal bleeding. It may increase the risk of cardiovascular diseases, and individuals with a history or risk factors for heart disease or stroke should monitor their condition closely, taking immediate action if cardiovascular symptoms arise. This medication can cause severe problems such as bleeding, ulcers, or perforations in the stomach or intestines, and particularly elderly individuals or those with a history of gastrointestinal diseases should use it cautiously. If gastrointestinal symptoms occur during use, consult a doctor immediately. It should not be used in patients with a history of peptic ulcers, severe blood disorders, very poor liver or kidney function, severe heart failure, severe hypertension, allergies to this medication or nonsteroidal anti-inflammatory drugs, asthma or allergy history, or for pain treatment after coronary artery bypass surgery. Particular caution should be exercised when using this medication in patients with a history of peptic ulcers, blood disorders, bleeding tendencies, liver or kidney dysfunction, heart dysfunction, hypertension, allergy history, asthma, autoimmune diseases, elderly individuals, or those with allergies to specific pigments. If any adverse reactions such as respiratory distress, blood pressure decrease, hives, rash, gastrointestinal bleeding, peptic ulcers, liver dysfunction, kidney issues, neurological symptoms, skin rash, tinnitus, hearing loss, edema, or palpitations occur, discontinue use immediately and consult with a doctor. It is important to use the minimum effective dose and keep the duration of treatment as short as possible. Regular blood tests and liver and kidney function checks are required for chronic conditions, and appropriate use should be made for acute diseases according to symptoms. This medication may mask symptoms of inflammation or pain, potentially delaying the diagnosis of infectious complications; therefore, it should be used along with antibiotics in suspected infections, with careful monitoring of the condition. When taken with other nonsteroidal anti-inflammatory drugs, specific anticonvulsants, antihypertensives, diuretics, aspirin, lithium, anti-cancer drugs, anticoagulants, etc., the risk of side effects may increase due to interactions, requiring caution and adjustment of dosage or consulting a physician if necessary. It may pose risks to the fetus, particularly in the late stages of pregnancy; therefore, individuals who are pregnant or may become pregnant should consult a physician before taking this medication. Women who are breastfeeding are advised not to take this medication due to the potential transfer to breast milk and harm to the baby. It is best not to use in children under 2 years old as safety has not been confirmed, and both children and the elderly should take it at the minimum dosage with caution for any unusual symptoms. In case of overdose, symptoms may include drowsiness, indigestion, vomiting, etc., so individuals exhibiting these symptoms should seek medical treatment immediately. This medication should be kept out of reach of children and should not be transferred to other containers for safety. Care should be taken to maintain quality during storage.

Serious side effects

• Hives
• severe swelling (edema)
• chest tightness
• difficulty breathing
• cold sweat
• pallor
• hematemesis
• gastrointestinal bleeding
• peptic ulcer
• perforation

Mild side effects

• Abdominal discomfort
• stomach pain
• abdominal pain
• nausea
• vomiting
• loss of appetite
• indigestion
• heartburn
• diarrhea
• constipation

Drug interactions

Do not take this medication with other nonsteroidal anti-inflammatory drugs and naproxen derivatives. Phenytoin anticonvulsants, sulfa drugs, sulfonylureas for blood glucose control, propranolol and other beta-blockers, ACE inhibitors (e.g. captopril), loop and thiazide diuretics, probenecid, aspirin, lithium, methotrexate, coumarin anticoagulants (e.g. warfarin), zidovudine, and quinolone antibiotics (e.g. enoxacin).

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is important to maintain the storage temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and safety.

Appearance

An orange transparent oval soft capsule containing a colorless to light orange transparent content

Package unit

10 capsules (10 capsules/PTP*1)