Cramoxine Duo Tablet 500 mg (Amoxicillin · Clavulanate Potassium [7:1])

Adult dose

For severe infections and respiratory infections in adults, take 2 tablets orally every 12 hours (2 times a day).

This medication is a beta-lactam antibiotic and contains components similar to penicillin, so patients with a history of allergic reactions to this ingredient or other beta-lactam medications should not use it. In particular, those who have experienced anaphylaxis or severe skin reactions should avoid its administration. Patients with viral diseases such as infectious mononucleosis or lymphocytic leukemia may be at a higher risk of developing rashes, so caution is required. Patients with liver function issues should be careful when using this medication, as it may cause recurrence of liver dysfunction. This medication contains lactose, so it should not be administered to patients with lactose intolerance or specific genetic metabolic disorders. Patients with decreased liver or kidney function may have increased drug concentrations, so careful consideration of dosage adjustment and dosing intervals is necessary. Patients who are allergic or have weak digestive function should also be cautious. Side effects such as diarrhea, vomiting, and abdominal pain may occur during use; in severe cases, serious colitis such as pseudomembranous colitis may manifest, so if any symptoms occur, the medication should be discontinued immediately and a physician should be consulted. There may be signs of liver function abnormalities; therefore, for long-term use, regular liver function tests should be conducted, and if allergic symptoms such as skin rashes or respiratory distress occur, medication should be discontinued immediately. This medication can also affect the blood and may rarely result in decreased blood cell counts or tendency for bleeding, so if any unusual symptoms occur, it should be discussed with healthcare professionals. Pregnant women or women who might become pregnant should particularly avoid taking this medication during the first three months, and nursing mothers should be cautious as their babies may experience side effects such as diarrhea or skin rashes. It is recommended to use this medication only for children over 12 years or weighing more than 40 kg, and elderly patients require careful monitoring for potential side effects due to decreased bodily functions. This medication might interact with other drugs, so if taken with anticoagulants, certain antibiotics, or anti-inflammatories, it is important to inform the physician, and regular blood tests as well as liver and kidney function tests are advisable during medication use. In case of overdose, gastrointestinal symptoms, kidney damage, or severe allergic reactions may occur, so immediate medical attention is necessary. Finally, this medication should be stored in a dry place at temperatures below 25 degrees Celsius, and it is important to take it only for the prescribed period as directed by a physician to prevent the emergence of resistant bacteria.

Serious side effects

Urticaria, mucosal membrane syndrome (Stevens-Johnson syndrome), shock, anaphylaxis, angioedema, serum sickness, acute generalised exanthematous pustulosis, dyspnea, laryngeal edema, anaphylactic shock, cholestatic jaundice, hepatitis, sudden severe headache, seizures, consciousness confusion, paralysis, acute kidney failure, interstitial nephritis, hematuria, severe swelling, increased blood pressure, aseptic meningitis, fever, thrombocytopenic purpura, leukopenia

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This medication should be stored in a sealed container to prevent moisture, in a cool place between 1 degree and 25 degrees Celsius. Additionally, it is important to keep it in a dry area.

Appearance

White oval film-coated tablet

Package unit

80 tablets (8 tablets/PTP x 10), 160 tablets (8 tablets/PTP x 20)