Cloaran Tablet 375 mg [Amoxicillin Hydrate. Clavulanate Potassium (2:1)]

Adult dose

For adults and children over 12 years of age or weighing 40 kg or more, administer 250 mg/125 mg of amoxicillin/clavulanate potassium per dose, orally 3 times a day every 8 hours. In cases of severe and respiratory infections, the dose may be increased to 500 mg/125 mg per dose. For patients with renal impairment, adjust the dose based on creatinine clearance. - Creatinine clearance of 10-30 mL/min: Administer 250-500 mg of amoxicillin per dose every 12 hours.

Child dose

For children under 12 years of age or weighing less than 40 kg, administer 250 mg/125 mg of amoxicillin/clavulanate potassium per dose, orally 3 times a day every 8 hours. In cases of renal impairment, use the same dosing as for adults.

This medication is a beta-lactam antibiotic and should not be used in patients with allergies to penicillins or cephalosporins. Particularly, individuals who have experienced severe allergic reactions or skin conditions in the past should avoid this medication. Patients with infectious mononucleosis or lymphocytic leukemia are at a higher risk for skin rashes and should use this medication with caution. Patients with impaired liver function should use it carefully as liver function may worsen. Patients with moderate to severe renal impairment should adjust the dosing intervals, as the drug can accumulate in the body and cause side effects. Patients with allergic tendencies or bronchial asthma should also use this medication with caution. Elderly individuals or those in poor overall health may be at risk of bleeding due to vitamin K deficiency, and caution is necessary. Patients with gastrointestinal diseases who experience significant vomiting or diarrhea may have reduced drug absorption, so caution is advised. Symptoms such as diarrhea, vomiting, and abdominal pain may occur upon taking this medication, and in rare cases, severe colitis may develop, requiring careful monitoring of symptoms. Abnormal liver function may arise, especially in the elderly and males, necessitating regular liver function tests with long-term use. Skin rashes, itching, and severe skin reactions such as Stevens-Johnson syndrome may occur and should prompt immediate discontinuation of the medication. Rare reports of blood-related reactions such as leukopenia, anemia, and thrombocytopenia have been noted, and tests may be required if abnormal symptoms occur. Central nervous system reactions such as anxiety, confusion, and seizures may occur rarely, particularly in patients with poor renal function or with high doses. Patients with renal impairment are at risk of acute renal failure, requiring regular testing. This medication may affect the normal intestinal microbiota, leading to phenomena like candidiasis. Symptoms of vitamin K deficiency bleeding or vitamin B-group deficiency may rarely occur, so symptom monitoring is essential. Extended use of this medication may lead to drug-resistant bacteria; therefore, it is important to take it for the minimum necessary duration. Serious allergic reactions, such as anaphylaxis, can very rarely occur, so patients should be closely monitored after administration. If severe diarrhea or abdominal cramps occur during or after antibiotic use, the medication should be discontinued immediately, and a physician should be consulted. This medication may interact with other drugs, so patients should inform their healthcare provider of any other medications they are taking. It should be avoided during the early stages of pregnancy, and pregnant or breastfeeding women should consult a physician before using this medication. It is not recommended for children under 12 years of age or those weighing less than 40 kg. Elderly individuals may experience adverse reactions more easily due to reduced bodily functions, so dosage and administration intervals should be adjusted, with careful monitoring. In case of overdose, symptoms such as vomiting, diarrhea, drowsiness, and rashes may occur; if suspected, immediate notification of healthcare providers and appropriate treatment are necessary.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, anaphylaxis, mucocutaneous syndrome (Stevens-Johnson syndrome), shock, fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme drowsiness, sudden severe headache, lightning headache, seizures,

Mild side effects

• Diarrhea
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain
• abdominal distension

This medication should be stored in a sealed container to prevent moisture and should be kept in a dry place below 25 degrees Celsius. Storing this way helps maintain the drug's efficacy and prevents degradation.

Appearance

Oval film-coated tablets that are white or almost white

Package unit

100 tablets/PPT [(10 tablets x 10)]