Roxepin Tablets (Loxoprofen Sodium Hydrate)

Adult dose

1. For indications 1 and 2 ○ Adults: Administer 60 mg of sodium loxoprofen (as the anhydrous form) orally three times a day. For a single dose, administer 60-120 mg orally. 2. For indication 3 ○ Adults: Administer 60 mg of sodium loxoprofen (as the anhydrous form) orally. It can be administered up to a maximum of 180 mg per day, ideally twice daily. It is advisable to avoid taking it on an empty stomach.

This medication should be discussed with a healthcare provider or pharmacist before use by individuals who consume alcohol regularly in amounts exceeding a certain limit. Taking this medication may lead to serious problems such as gastrointestinal bleeding in frequent alcohol users. This medication may increase the risk of cardiovascular diseases, so those with a history of heart disease or stroke or who have risk factors should exercise extra caution. If any cardiovascular abnormalities occur while taking it, inform your healthcare provider immediately. Furthermore, this medication has the potential to cause serious gastrointestinal issues such as bleeding, ulcers, and perforation. Extra caution should be exercised by older patients or those with a history of gastrointestinal disorders, and any gastrointestinal symptoms should be treated immediately. Do not use this medication in patients with peptic ulcers, severe liver or kidney diseases, heart failure, drug allergies, late-term pregnant women, nursing mothers, or patients with inflammatory bowel diseases. Patients with a history of peptic ulcers or liver or kidney function problems, hypertension, heart failure, blood coagulation disorders, or asthma should use this medication with caution and be monitored regularly by a healthcare provider. If hypersensitivity reactions such as rash, itching, respiratory distress, or low blood pressure occur while taking this medication, discontinue use immediately and seek medical assistance. Gastrointestinal symptoms may include abdominal pain, nausea, vomiting, diarrhea, and in severe cases, bleeding symptoms may appear, so caution is advised. This medication may cause neurological side effects such as drowsiness or dizziness, so caution is needed when driving or operating machinery. Regular blood tests and liver/kidney function tests are necessary as there is potential for liver and kidney dysfunction. The risk of side effects increases when this medication is taken in conjunction with other non-steroidal anti-inflammatory drugs, so it is advisable not to use them together. Particularly, there may be interactions with blood pressure medications, diuretics, anticoagulants, antibiotics, and antidepressants, so if you are taking any other medications, inform your healthcare provider or pharmacist. During pregnancy, especially in late stages, it may be harmful to the fetus, so it should not be used, and it is also safer not to take this medication while breastfeeding. Safety in pediatric patients has not been established, so it is recommended not to use this medication in children. Elderly patients are at higher risk for side effects, therefore they should take this medication with greater caution and consult with their healthcare provider immediately if any unusual symptoms arise. This medication should be kept out of reach of children and caution must be taken as transferring it to another container may affect its quality.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, shock, anaphylaxis-like symptoms, peptic ulcers, hematemesis, rectal bleeding, melena, severe gastrointestinal bleeding, intestinal perforation, acute renal failure, liver dysfunction, jaundice, fulminant hepatitis, hepatic necrosis, liver failure, interstitial pneumonia, asthma attacks, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, acute generalized exanthematous pustulosis, angioedema, facial swelling

Mild side effects

• Occasionally
• rash
• itching
• fever
• abdominal pain
• discomfort in the upper abdomen
• loss of appetite
• nausea
• vomiting
• diarrhea

This medication should be stored in a tightly sealed container to protect it from air and moisture. The storage temperature should preferably be maintained at room temperature between 1 and 30 degrees Celsius. This will help maintain the effectiveness of the drug for a longer period.

Appearance

White to pale yellow round tablets

Package unit

30 tablets/bottle, 300 tablets/bottle