Clif-Extended Release 375 Milligrams (Cefaclor Hydrate)

Adult dose

As cefaclor, administer 375 mg (potency) orally, twice a day. For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), continue treatment for more than 10 days. The tablets should be taken whole and must not be divided, crushed, or chewed. Administration can be done irrespective of meals, but absorption is increased when taken with food.

This drug is an antibiotic that kills bacteria by binding to certain proteins and disrupting bacterial cell wall synthesis. You must inform your doctor if you have previously experienced severe allergic reactions or shock from this medication. Persons allergic to this medication or similar cephalosporin antibiotics should not take this medicine. Those who are allergic to penicillin antibiotics or who have a predisposition to allergic symptoms such as bronchial asthma, rash, and urticaria should use this medication with caution. Patients with severely impaired kidney function or gastrointestinal diseases, especially with a history of colitis, should use this medication carefully. Elderly patients or those with poor overall health, and patients who have difficulty taking orally should be monitored closely for possible vitamin K deficiency symptoms. This medication can rarely cause serious allergic reactions, skin rash, blood disorders, liver or kidney impairment, gastrointestinal disturbances, respiratory problems, central nervous system abnormalities, and if symptoms appear, immediate consultation with a doctor is necessary. In particular, if there is a severe rash, blistering, or mucosal damage to the skin, discontinue taking the medication and visit a hospital immediately. Long-term use of this medication can lead to resistant bacteria; therefore, it is important to adhere to the prescribed duration and dosage set by your doctor. There may be interactions when taken with other medications, so you must inform your doctor about other medications being taken. Particularly, care is needed when taken together with probenecid, antacids, medications affecting the kidneys, anticoagulants, and oral contraceptives. Women who are pregnant or may become pregnant should consult a doctor before taking this medication to make a careful decision if it is necessary, and caution is also advised while breastfeeding as the medication may be transmitted in breast milk. Safety and efficacy in children have not been confirmed sufficiently; therefore, special caution is needed when administering to children. Overdosage may cause nausea, vomiting, abdominal discomfort, diarrhea, etc., and in such cases, immediate medical attention should be sought for proper treatment.

Serious side effects

• Urticaria
• edema
• dyspnea
• anaphylactic symptoms
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• agranulocytosis
• granulocytopenia
• pancytopenia
• anemia

Mild side effects

• General flushing
• vasodilation
• vascular edema
• sensory disturbances
• fainting
• hypertension
• rash
• itching
• fever
• lymphadenopathy

This medication should be stored in a tightly sealed container to prevent exposure to air and humidity, and it is recommended to store it at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the efficacy of the medication.

Appearance

Blue elongated extended release tablet

Package unit

30 tablets/bottle, 100 tablets/bottle