Daehan Ascorbic Acid Injection

Adult administration

As ascorbic acid, administer 50 to 1,000 mg daily, divided into 1 to several subcutaneous, intramuscular, or intravenous injections. Adjust according to age and symptoms.

This drug is an ampoule injection, and the glass container must be carefully cut before use. Glass particles can mix with the injection solution and cause adverse reactions. Extra caution is required when using this drug in children or elderly individuals. This drug should not be administered to certain patients. For example, individuals allergic to this drug or its components, patients with hyperoxaluria or Mediterranean anemia, patients with gout or cystinuria, and those with G6PD deficiency should not use this drug. Also, individuals with kidney oxalate stones should not receive more than 1 gram per day. Sodium bisulfite is included and may cause allergic reactions, therefore, patients with asthma need to be cautious when using this drug. In some patients, severe asthma attacks may occur. Using this drug may result in side effects such as nausea, vomiting, diarrhea, heartburn, abdominal cramps, fatigue, flushing, headache, and insomnia. Administering more than 1 gram per day may increase the risk of diarrhea and kidney stones, and doses above 600 milligrams may cause diuretic effects. Patients with G6PD deficiency should be cautious due to the risk of hemolysis. Excessive intake of ascorbic acid can cause the precipitation of oxalate or other substances in the urinary tract, so caution is needed. This drug is usually taken orally, but injections should only be used in acute situations or when oral intake is difficult. If oral administration is possible, it is advisable to switch back quickly. This drug can interact with other medications. Salicylates may interfere with the absorption of this drug, and caution is needed when using it with aspirin, nicotine, alcohol, certain appetite suppressants, iron supplements, anticonvulsants, oral contraceptives, and tetracycline antibiotics as side effects may occur. High doses may also reduce the effectiveness of oral anticoagulants. Some psychiatric medications may also interact, so consultation with a professional is needed when combined. The safety of this drug during pregnancy has not been fully established, so it should only be used when the benefits outweigh the risks. High doses above 1 gram should be avoided, as they may pose a risk of scurvy to newborns. While this drug can be transmitted through breast milk, no significant risks to the baby have been reported with regular doses. This drug may affect certain clinical test results. For example, false-negative reactions may appear in urine tests for sugar or blood tests, which should be noted during testing. Overdose may increase the risk of diarrhea and kidney stones, and diuretic effects may occur. If overdose symptoms occur, administration should be stopped immediately and appropriate treatment should be provided. During injection, there may be temporary pain at the injection site. For subcutaneous or intramuscular injections, only use the necessary minimum dose, and take care not to inject repeatedly in the same area. Extra caution is especially needed in newborns or children. If severe pain or blood reflux is observed when inserting the needle, it should be removed immediately. Intravenous injections should be administered slowly to prevent dizziness or phlebitis. Finally, this drug should be stored out of reach of children, in a dry place away from direct sunlight. It should not be transferred from its original container to another container and must be stored securely sealed.

Serious side effects

Severe allergic reactions such as anaphylaxis, asthma attacks, hemolysis, kidney stones, increased risk of diarrhea and kidney stones

Mild side effects

• Nausea
• vomiting
• diarrhea
• heartburn
• abdominal cramps
• fatigue
• flushing
• headache
• insomnia
• mild injection site pain

This drug should be stored in a sealed container to protect it from air and moisture. Therefore, it is important to keep the container tightly closed to maintain the effectiveness of the drug.

Appearance

A colorless, almost colorless transparent liquid contained in a colorless transparent ampoule

Package unit

2 mL × 50 ampoules