Will there be any resistance issues with Maunza?

I'm getting easily swayed by the fact that Maunjaro is said to be very effective.

But I can't be a pitcher for the rest of my life, and I'll have to quit someday.

I am worried about whether there will be any resistance issues.

After seeing results from Maunza, you'll need to manage your weight on your own to maintain it without the yo-yo effect.

If I gain the weight back immediately and go back to using Mountza, won't I develop a tolerance and it won't be very effective?