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When I have a headache, I try acupressure on my head and neck, and I also try to endure it.
The most effective thing, no matter what, is Tylenol.
Usually, taking one pill, and on particularly painful days, taking two pills, I can feel the headache disappear within 30 minutes to an hour.
Since the pain relievers are effective, I buy 10 tablets at a time from the pharmacy, but I often purchase them in bulk.
When you're sick, I think the fastest-acting remedy is the best.