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When I experience excessive stress or fatigue, I always get a migraine. During those times, the pain tends to worsen and become more difficult as time passes, so I take one 500mg Tylenol. The medication works quickly and is very effective, so I always keep it at home as a staple and carry it in my bag. It starts to dissolve immediately upon taking, fully dissolving within 5 minutes, and the effects appear in about 15 minutes, as advertised. I don't think there's any headache medicine that compares to Tylenol.