What causes ankylosing spondylitis?

Ankylosing spondylitis: Why do some people get it and others don't?

 

 

Ankylosing spondylitis is a disease that causes pain and stiffness in the lower back and hip joints. The stiffness is particularly severe in the morning and improves with movement. This condition can worsen over time, making it difficult for patients.

 

Then what the heck Causes of ankylosing spondylitis What is it? Rather than explaining it with one or two reasons, it's more accurate to say that it's caused by a complex intertwining of various factors.

 

The biggest Causes of ankylosing spondylitis It's genetic. People with a gene called HLA-B27 are at a much higher risk of developing ankylosing spondylitis. It's almost like being born with a predisposition to the disease. However, not everyone with this gene will develop ankylosing spondylitis.

 

This is due to other factors besides genetic factors. Causes of ankylosing spondylitis This means that it acts as a . Recent studies have shown that in addition to HLA-B27, there are other genes that affect the inflammatory response. Causes of ankylosing spondylitis It was found to have an effect on .

 

It is also important that our body's immune system causes problems based on genetics. Causes of ankylosing spondylitis This is it. The immune system is supposed to protect our bodies, but in ankylosing spondylitis, an "autoimmune response" occurs, attacking the body's own joints and causing inflammation. Excessive levels of certain inflammatory substances (cytokines) also occur. Causes of ankylosing spondylitis It is closely related to inflammation. For example, if there is an increase in a substance called TNF-alpha, inflammation can become more severe.

 

Plus, gut health too Causes of ankylosing spondylitis There is talk that it may be related. If the balance of bacteria living in the intestines is broken, the intestinal wall becomes weak, and this activates the immune response, which can lead to systemic inflammation, namely ankylosing spondylitis.

 

Environmental factors such as smoking, activities that repeatedly strain the joints, or certain bacterial infections Causes of ankylosing spondylitis We believe this could be the case. These environmental factors could act as a trigger for disease in genetically vulnerable individuals.

 

Like this Causes of ankylosing spondylitis It can be seen that it is caused by a complex interaction of genetic factors, immune system abnormalities, intestinal health, and environmental factors.

 

Causes of ankylosing spondylitis Continuing to research this will greatly help us detect this disease earlier and develop treatments tailored to each patient. .