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A study has found that the keto diet helps immune cell function and enhances the effectiveness of cancer treatment.
The keto diet refers to a 'low-carb, high-fat diet' that reduces carbohydrate intake and increases fat intake, and is an abbreviation of the ketogenic diet. It consists of reducing the proportion of carbohydrates to 5–10% of total caloric intake, 15–20% protein, and 70–80% fat.
The keto diet restricts the intake of carbohydrates, which are the body's primary energy source, causing the body to break down stored fat and use it as an alternative energy source.
It is known that ketone bodies are produced during the process of fat breakdown, and that when a state of ketosis is reached with increased blood ketone body concentration, the breakdown of body fat becomes more active.
A research team from the Perelman School of Medicine and Abramson Cancer Center at the University of Pennsylvania
▲ The effects of a keto diet, a high-fiber diet, a high-fat diet, a high-protein diet, and a high-cholesterol diet on the tumor-fighting ability of CAR-T cells were analyzed.
CAR-T therapy is a treatment method that uses a patient's own immune cells to kill cancer cells. It is a personalized treatment in which T cells, which are immune cells from the patient's body, are genetically modified to attack cancer cells and then injected into the patient.
Analysis results showed that the keto diet most activated the tumor-fighting function of CAR-T cells compared to other diets.
The research team analyzed that beta-hydroxybutyrate (BHB), a metabolite produced in the liver after consuming a keto diet, inhibits tumor growth and enhances the effectiveness of CAR-T therapy. Since CAR-T cells use BHB as an energy source instead of glucose, increasing BHB levels in the body allows CAR-T cells to eliminate cancer cells more effectively.
In fact, when the research team analyzed blood samples from patients who received CAR-T therapy, the higher the BHB levels, the more the CAR-T cells expanded.
Meanwhile, the results of this study were recently presented at the 66th Annual Meeting of the American Society of Hematology (ASH).
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Cancer is a disease that one must never get, but,
It looks like the keto diet is helpful.
Reduce carbohydrates
Increasing fat intake
A diet good for immune function
It looks like it's keto.