Our children's fever reducer is Maxibuphen syrup.

 

Hello

This is Geum-eun's mom.

 

 

Our house has Maxibuphen syrup and Anipen syrup as fever reducers.

 

I had previously used the champ as well, but since Pink's champ has been fully recalled,

I threw away not only the pink champion I had but also the blue champion.
For some reason, the child is not using it currently.

 

Both syrups were prescribed at the hospital.

Similarly, I am using Maxibuphen, which is more familiar, as it contains dexibuprofen.

 

It's a fever reducer I've been using since my first childbirth, and since it's prescribed, I trust it more.

 

Maxibuphen syrup is one of the isomers of ibuprofen, an antipyretic and analgesic component.

It is a fever reducer that contains only dexibuprofen, which is a pure active ingredient.

 

Dexibuprofen is

It provides the same effect with a lower dose than ibuprofen.

It is characterized by reduced side effects caused by inactive substances.
You can purchase the medication at the pharmacy with a hospital prescription, or you can buy it directly at the pharmacy without a prescription.

Maxibuphen syrup is

Using natural colorants with a grape scent

Even infants and young children who have difficulty taking medication do not feel a sense of rejection.

The advantage is that it is easy to take.

 

 

If there is a slight inconvenience, the measurement marks on the cup used for pouring syrup are white, so they are hard to see.

Anipen syrup has black markings on the cup container, making it easy to see, so sometimes I use the cup container of Anipen syrup, which is not a secret.

 

 

Please refer to the back side for instructions and dosage next to the antipyretic label.

The sticker is designed to be easily peeled off and reattached, so it's convenient.

 

If there had been a separate manual, there would have been a risk of losing it and it would have been inconvenient to find it every time, so I appreciated these thoughtful details.

 

 

As you can see from the container, the color is pink, and it has a slightly viscous form.

 

※ AniPen syrup is white in color and has a similarly viscous consistency.

I took a picture together so you can compare.

 

 

Then I will look into the Maxibuphen syrup I am using.

 

 

● Ingredients/Content

 

Dexibuprofen 12mg/mL

 

Antipyretic, anti-inflammatory, and analgesic drugs (non-steroidal anti-inflammatory drugs)
Because it inhibits COX-1 and COX-2 enzymes involved in the production of prostaglandins that cause inflammation, fever, and pain

Anti-inflammatory, antipyretic, and analgesic effects

 

● Medication

 

Children over 6 months old
Single dose of 0.4~0.6mL/kg (equivalent to 5~7mg/kg of dexibuprofen)

Take as needed every 4 to 6 hours.
Up to 4 times a day (28 mg/kg)

Children weighing 30kg or less

Maximum of 25mL per day (equivalent to 300mg of dexibuprofen)

 

The single dose can be administered as follows depending on body weight or age.
If you know your weight, it is more appropriate to take the medication according to the dosage based on your weight.

 

Please refer to the table below.

 

Age	Weight (kg)	Single dose (ml)	Dosage of dexibuprofen 1 dose (mg)
12 years old	Over 43 kg	18 to 25 mL	215~300 mg
11 years old	38.0~42.9 kg	16 to 25 mL	190~300 mg
Ages 9-10	30.0~37.9 kg	12.5~22 mL	150~265 mg
Ages 6 to 8	21.0~29.9 kg	9 to 17 mL	105~210 mg
4 to 5 years old	16.0~20.9 kg	7 to 12 mL	80 to 145 mg
2 to 3 years old	12.0~15.9 kg	5 to 9 mL	60~110 mg
12-23 months	10.0~11.9 kg	4 to 7 mL	50 to 80 mg
6-11 months	7.9~9.9 kg	3 to 6 mL	40 to 70 mg

It is very important to follow the correct usage instructions for medications.

In particular, for children, it is essential to use the correct dosage and administration according to their age and weight.

 

I'll also explain how to calculate the single dose.

 

Maxibuphen
Half of the body weight

You can feed up to that point.

 

If you take the medication throughout the day at the minimum dosing interval, you may exceed the maximum limit, so it's very important to always check the maximum daily dosage!!

 

 

Ibuprofen
A mixture of S-ibuprofen and R-ibuprofen

The substance that primarily exerts the actual therapeutic effect is mainly S-ibuprofen (dex-ibuprofen).

Dexibuprofen
Remove R-ibuprofen, which causes side effects, from the mixture.

A medication composed solely of S-ibuprofen, which exhibits antipyretic, analgesic, and anti-inflammatory effects.
​

→ Dexibuprofen compared to Ibuprofen

Not only is the fever-reducing effect rapid, but also,

It produces effects similar to ibuprofen even in small amounts.

It is said that side effects such as stomach discomfort, including heartburn that are essential when taking antipyretic and analgesic medications, occur less frequently.

 

★

 

When should I give the fever reducer?

 

The Korean Pediatric Society

Mild fever when armpit temperature exceeds 37.3°C

If the temperature is 39.0°C or higher, it is considered a high fever.

We recommend visiting the hospital if the temperature exceeds 38°C.

However, in infants, body temperature is higher and changes more rapidly than in adults.

Rather than giving antipyretics immediately when you have a fever

They recommend using it when the baby is crying or fussing and having a hard time.

 

▶ Classification of antipyretics

 

Painkillers

Antipyretic and analgesic medication containing acetaminophen as the main ingredient

It is classified as a non-steroidal anti-inflammatory drug (NSAID).

 

The most representative ingredient among non-steroidal anti-inflammatory drugs is ibuprofen.

 
Dexibuprofen is the active ingredient separated from ibuprofen.

Ibuprofen and dexibuprofen also have anti-inflammatory effects that reduce inflammation, and are classified as antipyretic, analgesic, and anti-inflammatory agents.

There are several other types as well, but mainly for infant fever relief.

Three types—acetaminophen, ibuprofen, and dexibuprofen—are widely used.

Acetaminophen is Tylenol, Champ Syrup, and Ibuprofen is Brufen Syrup
Dexibuprofen is well known as Maxibuphen syrup.

Only acetaminophen (Tylenol) can be administered before 6 months of age.

After six months, both acetaminophen and ibuprofen (Brufen) can be administered.

 

▶ Types of fever reducers

 

The dexibuprofen I use, as I explained earlier, I'll also explain the other antipyretics.

 

◆ Acetaminophen
Tylenol Suspension, Champ Pink, ColdAwon Kids Pen Syrup

​

Tylenol Suspension (Cherry Flavor), Champ Syrup (Cherry Flavor), and Coldaone Kids Pen (Strawberry Flavor) syrups all contain acetaminophen as the main ingredient.

Acetaminophen can be administered to babies over 4 months old, and

It can be taken safely with fewer side effects of gastrointestinal disorders.

When should I feed the baby again after they have vomited just in case?

You can have Tylenol, which has fewer gastrointestinal side effects, at about 80% of the standard dosage.

 

※ Acetaminophen, unlike ibuprofen or dexibuprofen,

It does not inhibit Cox-1 enzyme that protects the mucous membrane, resulting in fewer gastrointestinal issues and allowing it to be taken on an empty stomach.

The single dose for children is as follows.

 

Since children's weights vary from infancy, it is best to administer according to their weight.
Please ensure that the daily dose does not exceed 75 mg per kilogram.

 

I'll show you how to calculate the dosage.

Multiply the weight by 1/3 and round to the nearest decimal place before administering (for example, for an 8kg child, 3cc; for a 10kg child, 4cc).
If you have a fever for a day, it is also possible to divide the dose into three parts of 0.4ml based on body weight and administer it.

 

◆ Ibuprofen

Bluepen Syrup, Champ Ibuprofen, Cold One Ibuprofen Syrup

 

 

Ibuprofen is the most representative ingredient of non-steroidal anti-inflammatory drugs, serving as an analgesic, antipyretic, and anti-inflammatory agent.

Unlike acetaminophen, it is characterized by also acting as an anti-inflammatory drug that reduces inflammation.

In cases of fever caused by inflammation such as otitis media or tonsillitis

It is better to have you take a Brufen-type medication rather than Tylenol.

 

Ibuprofen has a faster fever-reducing effect compared to acetaminophen.

It is said that the effectiveness of acetaminophen 15 mg/kg and ibuprofen 10 mg/kg in reducing fever is the same.

The single dose for children is as follows.

 

It is appropriate to administer 5 to 10 mg/kg of ibuprofen syrup per dose.

 

Age	Recommended single dose of ibuprofen	Single dose amount
1-2 years old	50-100mg	3-5ml
Ages 3-6	100-150mg	5-8 ml
7-10 years old	150-200mg	8-10ml
11-14 years old	200-250mg	10-13 ml

 

I'll also explain how to calculate the single dose.

 

Blue pen
One-third of the body weight (excluding decimal places)
For example, a 8kg child receives 2cc, and a 10kg child receives 3cc.

If you take the medication throughout the day at the minimum dosing interval, the maximum dose may be exceeded, so please!! Make sure to check the maximum daily dosage.

 

▶ What is cross-using fever reducers for babies?

 

Cross-medication

In case a fever does not subside with a single antipyretic medication

It refers to taking fever reducers containing different ingredients alternately.

Medications with the same ingredients are taken at 4 to 6-hour intervals.

When alternating between different types of medication, they can be taken at intervals of 2 to 3 hours.

However, alternating antipyretics every time the child has a fever is

It can be dangerous because you might end up taking more medication than necessary.

 

Generally, in cases of fever

A single antipyretic medication, not a combination therapy

It is okay to take it at intervals of 4 to 6 hours (Tylenol every 4 hours, Brufen every 6 hours).

In the case of children under 5 years old

Since seizures can occur along with high fever

Since alternating antipyretics can be helpful

It is best to only take cross-medications when prescribed by the hospital.

 

In the case of concurrent medication use
Are ibuprofen and dexibuprofen in the same class?

These two should not be taken concurrently.

 

Acetaminophen → Ibuprofen
Acetaminophen → Dexibuprofen

 

You can take it with cross-dosing.

 

As a reference, another method to reduce fever is lukewarm water massage.
It's a widely used method besides antipyretics.

 

The principle is to evaporate heat through the surface of the skin.

By continuously rubbing the skin with a sponge or towel soaked in lukewarm water, the heat is reduced.

I also had a child around 3 months old.

When there was a high fever and it was not possible to give antipyretics

This is the method used before going to the hospital.

At that time, I was anxious and worried.

I remember feeling relieved when my fever went down with this method, and then I watched over it before visiting the hospital.

 

The disadvantage is actually stimulation of the sympathetic nervous system.

It can raise body temperature, and the fever-reducing effect is temporary.

Additionally, the child may find it difficult and challenging to cooperate, and may cry.

 

★

 

It is important to check if the prescribed medication contains an antipyretic and to not exceed the maximum daily dose.

 

It would be good to know well and carefully follow the instructions when giving fever medicine to our child.
I was very glad to have the opportunity to learn a lot through this experience.

I hope it will also be helpful to our neighbors.