Will I develop resistance to probiotics if I take them for a long time?

After suffering from irritable bowel syndrome and constipation, I have been taking probiotics on an empty stomach.

I have been taking probiotics for over a year now.

It was effective at first, but now

It's no longer effective.

I am taking it at the same time as when I first started, but it is not having any effect. Do probiotics also have resistance?

I'm really conflicted because I have to repurchase this.